Evidence for a Pathway Independent from 2′‐Deoxyguanosine and Reversible by IL‐2 by which Purine Nucleoside Phosphorylase Inhibitors Block T‐Cell Proliferation

@article{Boehncke1994EvidenceFA,
  title={Evidence for a Pathway Independent from 2′‐Deoxyguanosine and Reversible by IL‐2 by which Purine Nucleoside Phosphorylase Inhibitors Block T‐Cell Proliferation},
  author={W. Boehncke and R. Gilbertsen and J. Hemmer and W. Sterry},
  journal={Scandinavian Journal of Immunology},
  year={1994},
  volume={39}
}
Patients with homozygous deficiency of purine nucleoside phosphorylase (PNP) present with a T‐cell selective immune deficiency. To elucidate the potential use of PNP inhibitors in the therapy of cutaneous T‐cell lymphomas (CTCLs) the authors studied the effects of CI‐1000 (formerly PD 141955‐2) and CI‐972 on a T‐cell line My La established from a patient with mycosis fungoides. Both PNP inhibitors had significant, dose‐dependent, inhibitory effects on the proliferation of the T‐cell line. CI… Expand
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