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Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism.
TLDR
Neither the urinary S-/R-mephenytoin ratio nor the dextromethorphan metabolic ratio were altered significantly by coadministration of the probe drugs. Expand
Effects of Organic Anion, Organic Cation, and Dipeptide Transport Inhibitors on Cefdinir in the Isolated Perfused Rat Kidney
TLDR
The anionic secretory pathway was found to be the predominant mechanism for cefdinir renal excretion and this finding was confirmed by glycylsarcosine studies, indicating that reabsorption was mediated, at least in part, by the dipeptide transporter system. Expand
Animal‐to‐Human Dose Translation of Obiltoxaximab for Treatment of Inhalational Anthrax Under the US FDA Animal Rule
TLDR
The human dose of 16 mg/kg obiltoxaximab provided exposure beyond that of 16mg/kg in animals, ensuring a sufficient duration of PA neutralization to allow for adaptive immunity development and may be applicable to other agents being developed under the Animal Rule. Expand
Pharmacokinetics and Tolerability of Obiltoxaximab: A Report of 5 Healthy Volunteer Studies.
TLDR
On the basis of consistent results of 5 clinical trials in healthy volunteers, the pharmacokinetic properties of obiltoxaximab after a 16-mg/kg IV infusion can be considered adequately characterized, a criteria of the Animal Rule. Expand
Simplified Phenotyping with Dextromethorphan by Thin‐Layer Chromatography: Application to Clinical Laboratory Screening for Deficiencies in Oxidative Drug Metabolism
TLDR
The thin-layer chromatography (TLC) technique described in the present study is a rapid and inexpensive alternative to the methods currently available for assessing the urinary metabolic profile of DM. Expand
A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer's disease
TLDR
Elayta (CT1812) is a novel allosteric antagonist of the sigma‐2 receptor complex that prevents and displaces binding of Aβ oligomers to neurons and mitigates downstream synaptotoxicity and restores cognitive function in aged transgenic mouse models of Alzheimer's disease. Expand
Genetic Aspects of Drug Disposition and Therapeutics
TLDR
In the following overview, representative examples of genetic polymorphisms in the expression of drug receptors and metabolic enzymes are presented, with particular emphasis on polymorphic biotransformations. Expand
Achiral and chiral high-performance liquid chromatographic methods for clinafloxacin, a fluoroquinolone antibacterial, in human plasma.
TLDR
Achiral and chiral HPLC methods were developed for clinafloxacin, a quinolone antimicrobial agent, and accuracy was within 3.5% with a inter-assay precision of 5.4% over a quantitation range of 0.040 to 2.5 microg/ml. Expand
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