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CGS 27023A

Known as: CGS-27023A, CGS27023A 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Hydroxamic AcidsPyrazinesSulfonamides
MMI 270BMMI270

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Synthesis and evaluation of a novel hydroxamate based fluorescent photoprobe for imaging of matrix metalloproteinases.
The assessment of matrix metalloproteinase (MMP) activity in vivo is highly desirable in various human diseases such as cancers… 
2008
2008
Matrix metalloproteinase inhibitor, MMI270 (CGS27023A) inhibited hematogenic metastasis of B16 melanoma cells in both experimental and spontaneous metastasis models
Matrix metalloproteinases (MMP) have been implicated in several steps of tumor metastasis, such as invasion in the extracellular… 
2007
2007
Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function.
2007
2007
Establishment of a mouse skin model of the lichenification in human chronic eczematous dermatitis
Background  Repeated mechanical stresses, such as scratching and rubbing, on a lesional skin area induce a rough skin condition… 
Highly Cited
2006
Highly Cited
2006
Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome.
Alport syndrome is a glomerular basement membrane (GBM) disease caused by mutations in type IV collagen genes. A unique irregular… 
2004
2004
A dose-finding and pharmacokinetic study of the matrix metalloproteinase inhibitor MMI270 (previously termed CGS27023A) with 5-FU and folinic acid
The orally bioavailable matrix metalloproteinase inhibitor MMI270 reduces tumour growth metastasis in preclinical models. We… 
Highly Cited
2000
Highly Cited
2000
Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design
The high-resolution NMR solution structure of the catalytic fragment of human collagenase-3 (MMP-13) was used as a starting point… 
Highly Cited
1998
Highly Cited
1998
Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon…
The solubilization of plasma membrane receptors through proteolytic cleavage of the ligand binding domain at the cell surface is… 
Highly Cited
1997
Highly Cited
1997
Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits.
Structure-activity relationships of a lead hydroxamic acid inhibitor of recombinant human stromelysin were systematically defined… 
1995
1995
Oral administration of a matrix metalloproteinase inhibitor, CGS 27023A, protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits
Matrix metalloproteinases (MMP) are elevated in human osteoarthritic cartilage [1] and in cartilage from rabbits with… 
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