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MMI270

An orally-active synthetic hydroxamic acid derivative with potential antineoplastic activity. MMI270 inhibits a broad spectrum of matrix… Expand
National Institutes of Health

Papers overview

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2013
2013
Increased expression of matrix metalloproteinase-1 (MMP-1) and reduced production of type I collagen by dermal fibroblasts are… Expand
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2008
2008
Matrix metalloproteinases (MMP) have been implicated in several steps of tumor metastasis, such as invasion in the extracellular… Expand
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2006
2006
We have investigated the antitumor effects of synthetic MMP inhibitor MMI270 against postoperative lung metastasis from colon… Expand
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2006
2006
Alport syndrome is a glomerular basement membrane (GBM) disease caused by mutations in type IV collagen genes. A unique irregular… Expand
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Highly Cited
2005
Highly Cited
2005
Pulmonary fibrosis is characterized by a loss of lung epithelial cells, replaced by interstitial myofibroblasts to deposit… Expand
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2004
2004
Based on a previous report on the effect of a matrix metalloproteinase (MMP) inhibitory compound, MMI270, in regulating tumor… Expand
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2004
2004
Circulating endothelial progenitor cell (EPCs) have been reported to contribute to vasculogenesis in adult organisms. To… Expand
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2003
2003
Blood-brain barrier (BBB) disruption is a critical event leading to vasogenic brain edema and secondary brain damage after cold… Expand
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2003
2003
We investigated the anti-angiogenic effects of a matrix metalloproteinase inhibitor, (MMI), so called MMI270, against B16-BL6… Expand
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Highly Cited
2001
Highly Cited
2001
This Phase I study of MMI270, an p.o. administered matrix metalloproteinase inhibitor, assessed toxicity, pharmacokinetics, and… Expand
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