Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome.

@article{Rao2006RoleFM,
  title={Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome.},
  author={Velidi H Rao and Daniel T. Meehan and Duane C. Delimont and Motowo Nakajima and Takashi Wada and Michael Ann Gratton and Dominic E Cosgrove},
  journal={The American journal of pathology},
  year={2006},
  volume={169 1},
  pages={
          32-46
        }
}
Alport syndrome is a glomerular basement membrane (GBM) disease caused by mutations in type IV collagen genes. A unique irregular thickening and thinning of the GBM characterizes the progressive glomerular pathology. The metabolic imbalances responsible for these GBM irregularities are not known. Here we show that macrophage metalloelastase (MMP-12) expression is >40-fold induced in glomeruli from Alport mice and is markedly induced in glomeruli of both humans and dogs with Alport syndrome… CONTINUE READING

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