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CFLAR gene

Known as: I-FLICE, CASP8 and FADD like apoptosis regulator, CASP8- AND FADD-LIKE APOPTOSIS REGULATOR 
This gene plays a role in the regulation of both proteolysis and apoptosis.
National Institutes of Health

Related topics

Related topics

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ApoptosisCASP8 and FADD-Like Apoptosis Regulating ProteinCASP8 and FADD-Like Apoptosis Regulator ProteinCFLAR protein, human

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CFLAR wt Allele

Papers overview

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Highly Cited
2008
Highly Cited
2008
CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising antineoplastic agent because of its… 
Highly Cited
2007
Highly Cited
2007
Regulation of Tumor Cell Sensitivity to TRAIL-Induced Apoptosis by the Metastatic Suppressor Raf Kinase Inhibitor Protein via Yin Yang 1 Inhibition and Death Receptor 5 Up-Regulation
Raf-1 kinase inhibitor protein (RKIP) has been implicated in the regulation of cell survival pathways and metastases, and is… 
Highly Cited
2006
Highly Cited
2006
Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin
Induction of apoptosis by the death ligand TRAIL might be a promising therapeutic approach in cancer therapy. However, since not… 
Highly Cited
2004
Highly Cited
2004
c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations.
Highly Cited
2003
Highly Cited
2003
Increased expression of FLIP, an inhibitor of Fas‐mediated apoptosis, in stomach cancer
Despite the cell surface expression of Fas (Apo‐1/CD95), many types of tumor cells, including stomach cancer cells, are resistant… 
Highly Cited
2001
Highly Cited
2001
Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein.
Molluscum contagiosum virus contains two open reading frames, MC159 and MC160, that encode proteins with death effector domains… 
Highly Cited
2001
Highly Cited
2001
Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis
Highly Cited
2001
Highly Cited
2001
c-Rel Is Required for the Protection of B Cells from Antigen Receptor-Mediated, But Not Fas-Mediated, Apoptosis1
The NF-κB/Rel transcription factor family has been shown to protect many cell types from apoptotic signals. However, it is not… 
Highly Cited
1997
Highly Cited
1997
Cognitive-Behavioral Body-Image Therapy: Extended Evidence of the Efficacy of a Self-Directed Program
Scientific investigations support the effectiveness of cognitive-behavioral therapy (CBT) in the treatment of body… 
Highly Cited
1993
Highly Cited
1993
An experimental study of ?? ? hadrons at LEP
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