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Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention
It is becoming increasingly evident that CYP1A1 plays an important role in the detoxication of environmental carcinogens, as well as in the metabolic activation of dietary compounds with cancer preventative activity.
Zinc and respiratory tract infections: Perspectives for COVID-19 (Review)
- A. Skalny, L. Rink, A. Tinkov
- Medicine, BiologyInternational Journal of Molecular Medicine
- 14 April 2020
Signs suggest that zinc status may possess protective effect as preventive and adjuvant therapy of COVID-19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator-induced lung injury, modulation of antiviral and antibacterial immunity.
Cutaneous melanoma: From pathogenesis to therapy (Review)
The epidemiological features of cutaneous melanoma along with the biological mechanisms involved in its development and progression are summarized and the current state-of-the-art of advanced stage melanoma treatment strategies and the currently available evidence of the use of predictive and prognostic biomarkers are discussed.
Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems.
Physical and chemical characterization of an avian reovirus
Avian reovirus core particles were found to possess a transcriptase and a methylase activity and Antiserum against type 3 reov virus did not neutralize avian reOVirus.
Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos
The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation.
The tumor microenvironment in hepatocellular carcinoma (review).
The tumor microenvironment in hepatocellular carcinoma (HCC) was explored by a review of studies on hepatitis virus infections and the consequent chronic inflammatory status of the liver, and the rationale for targeting tumor-stromal interface is summarized.
p53 codon 72 polymorphism as a risk factor in the development of breast cancer.
- E. Papadakis, D. N. Dokianakis, D. Spandidos
- BiologyMolecular Cell Biology Research Communications
- 1 June 2000
It is suggested that p53 Arg homozygosity could represent a risk factor for the tumorigenesis of the breast.
Significant involvement of CCR2–64I and CXCL12–3a in the development of sporadic breast cancer
- A. Zafiropoulos, N. Crikas, A. Passam, D. Spandidos
- Biology, MedicineJournal of Medical Genetics
- 30 April 2004
A significant involvement of the chemokine system in the development of breast cancer is indicated by the determined genotype for the above four polymorphisms in 442 cancer samples and 361 control samples.
Malignant transformation of early passage rodent cells by a single mutated human oncogene
When linked to transcriptional enhancers, the mutant Ha-ras-1 gene from the T24 bladder carcinoma cell line induces the complete malignant transformation of early passage cells, while the normal…