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Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention
TLDR
It is becoming increasingly evident that CYP1A1 plays an important role in the detoxication of environmental carcinogens, as well as in the metabolic activation of dietary compounds with cancer preventative activity. Expand
Significant involvement of CCR2–64I and CXCL12–3a in the development of sporadic breast cancer
TLDR
A significant involvement of the chemokine system in the development of breast cancer is indicated by the determined genotype for the above four polymorphisms in 442 cancer samples and 361 control samples. Expand
Physical and chemical characterization of an avian reovirus
TLDR
Avian reovirus core particles were found to possess a transcriptase and a methylase activity and Antiserum against type 3 reov virus did not neutralize avian reOVirus. Expand
Mitochondrial genes as sites of primary action of steroid hormones
TLDR
The hypothesis of a direct effect of steroid hormones on mitochondrial gene transcription is postulated and the demonstrated effects of steroid (and thyroid) hormones on mitochondria transcription and respiratory enzyme biosynthesis are demonstrated. Expand
Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos
TLDR
The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation. Expand
Pathogenetic mechanisms and treatment options for ophthalmic pterygium: trends and perspectives (Review).
TLDR
Although pterygium management has traditionally involved surgery, often enhanced by the use of antimetabolites, recent advancements in the understanding of molecular and biochemical events underlying pteryGium pathogenesis may enable theUse of less invasive treatment methods. Expand
Interleukin 8 and cardiovascular disease.
TLDR
In the scientific literature, there is sufficient evidence to support beyond any doubt the involvement of IL-8 in the establishment and preservation of the inflammatory micro-environment of the insulted vascular wall. Expand
p53 codon 72 polymorphism as a risk factor in the development of breast cancer.
TLDR
It is suggested that p53 Arg homozygosity could represent a risk factor for the tumorigenesis of the breast. Expand
The tumor microenvironment in hepatocellular carcinoma (review).
TLDR
The tumor microenvironment in hepatocellular carcinoma (HCC) was explored by a review of studies on hepatitis virus infections and the consequent chronic inflammatory status of the liver, and the rationale for targeting tumor-stromal interface is summarized. Expand
CYP1A1, CYP19, and GSTM1 polymorphisms increase the risk of endometriosis.
TLDR
The data suggest that CYP19 VNTR (TTTA)(10) allele as well as the combined genotype CYP1A1 m1 polymorphism and GSTM1null deletion associate with the endometriosis phenotype, whereas the GSTT1 null deletion does not. Expand
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