CFLAR protein, human

Known as: CLARP protein, human, Cellular FLICE-Like Inhibitory Protein Short Isoform, MACH-Related Inducer of Toxicity Beta-1 
CASP8 and FADD-like apoptosis regulator isoform 2 (221 aa, ~25 kDa) is encoded by the human CFLAR gene. This protein is involved in the regulation of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the… (More)
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2009
2009
Phosphatase and tensin homologue (PTEN) loss and activation of the Akt-mammalian target of rapamycin (mTOR) pathway increases… (More)
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2009
2009
Cellular FLICE-inhibitory protein (c-FLIP) proteins are crucial regulators of the death-inducing signaling complex (DISC) and… (More)
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2008
2008
This study demonstrates that combined treatment with subtoxic doses of quercetin (3',3',4',5,7-pentahydroxyflavone), a flavonoid… (More)
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2007
2007
Certain classes of tumor cells respond favorably to TRAIL due to the presence of cell surface death receptors DR4 and DR5… (More)
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Highly Cited
2006
Highly Cited
2006
c-FLIP inhibits caspase 8 activation and apoptosis mediated by death receptors such as Fas and DR5. We studied the effect of c… (More)
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2006
2006
Death receptor signaling is initiated by the assembly of the death-inducing signaling complex, which culminates in the activation… (More)
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2006
2006
E2F1 is a transcription factor that plays a well-documented role during S phase progression and apoptosis. We had previously… (More)
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2003
2000
2000
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis of transformed and cancer cells… (More)
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