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CFLAR protein, human

Known as: CLARP protein, human, Cellular FLICE-Like Inhibitory Protein Short Isoform, MACH-Related Inducer of Toxicity Beta-1 
CASP8 and FADD-like apoptosis regulator isoform 2 (221 aa, ~25 kDa) is encoded by the human CFLAR gene. This protein is involved in the regulation of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full… Expand
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Highly Cited
2016
Highly Cited
2016
Summary The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis. DISC assembly and activation are… Expand
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Highly Cited
2011
Highly Cited
2011
Summary The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes… Expand
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2009
2009
BackgroundTRAIL is considered as a promising anti-cancer agent, because of its ability to induce apoptosis in cancer but not in… Expand
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Highly Cited
2008
Highly Cited
2008
This study demonstrates that combined treatment with subtoxic doses of quercetin (3′,3′,4′,5,7‐pentahydroxyflavone), a flavonoid… Expand
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Highly Cited
2006
Highly Cited
2006
c-FLIP inhibits caspase 8 activation and apoptosis mediated by death receptors such as Fas and DR5. We studied the effect of c… Expand
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Highly Cited
2006
Highly Cited
2006
Death receptor signaling is initiated by the assembly of the deathinducing signaling complex, which culminates in the activation… Expand
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Highly Cited
2003
Highly Cited
2003
Tumors display a high rate of glucose uptake and glycolysis. We investigated how inhibition of glucose metabolism could affect… Expand
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Highly Cited
2002
Highly Cited
2002
Primary B cells from B cell chronic lymphocytic leukaemia (B-CLL) were resistant to the novel selective cytotoxic agent, TNF… Expand
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Highly Cited
2000
Highly Cited
2000
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis of transformed and cancer cells… Expand
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