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CFLAR protein, human

Known as: CLARP protein, human, Cellular FLICE-Like Inhibitory Protein Short Isoform, MACH-Related Inducer of Toxicity Beta-1 
CASP8 and FADD-like apoptosis regulator isoform 2 (221 aa, ~25 kDa) is encoded by the human CFLAR gene. This protein is involved in the regulation of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full… Expand
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Highly Cited
2016
Highly Cited
2016
Summary The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis. DISC assembly and activation are… Expand
Highly Cited
2013
Highly Cited
2013
Triple-negative breast cancers (TNBCs) are clinically aggressive forms associated with a poor prognosis. We evaluated the… Expand
Highly Cited
2011
Highly Cited
2011
Summary The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes… Expand
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Review
2011
Review
2011
Cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein (c-FLIP) is a major resistance factor and critical anti… Expand
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Highly Cited
2008
Highly Cited
2008
This study demonstrates that combined treatment with subtoxic doses of quercetin (3′,3′,4′,5,7‐pentahydroxyflavone), a flavonoid… Expand
Highly Cited
2006
Highly Cited
2006
c-FLIP inhibits caspase 8 activation and apoptosis mediated by death receptors such as Fas and DR5. We studied the effect of c… Expand
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Highly Cited
2003
Highly Cited
2003
Tumors display a high rate of glucose uptake and glycolysis. We investigated how inhibition of glucose metabolism could affect… Expand
Highly Cited
2002
Highly Cited
2002
Primary B cells from B cell chronic lymphocytic leukaemia (B-CLL) were resistant to the novel selective cytotoxic agent, TNF… Expand
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Highly Cited
2000
Highly Cited
2000
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis of transformed and cancer cells… Expand
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