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CDGSH Iron-Sulfur Domain-Containing Protein 2, human

Known as: CDGSH Iron-Sulfur Domain Protein 2, CDGSH Iron-Sulfur Domain-Containing Protein 2, Nutrient Deprivation Autophagy Factor 1 
CDGSH iron-sulfur domain-containing protein 2 (135 aa, ~15 kDa) is encoded by the human CISD2 gene. This protein plays a role in the regulation of… 
National Institutes of Health

Related topics

Related topics

8 relations
AutophagyCISD2 geneIntegral Membrane ProteinsLigand Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer.
SIGNIFICANCE Cancer cells accumulate high levels of iron and reactive oxygen species (ROS) to promote their high metabolic… 
2017
2017
Interactions between mitoNEET and NAF-1 in cells
The NEET proteins mitoNEET (mNT) and nutrient-deprivation autophagy factor-1 (NAF-1) are required for cancer cell proliferation… 
2017
2017
Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates
NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that… 
Highly Cited
2016
Highly Cited
2016
Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells
ABSTRACT Maintaining iron (Fe) ion and reactive oxygen species homeostasis is essential for cellular function, mitochondrial… 
Review
2015
Review
2015
Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease.
Highly Cited
2015
Highly Cited
2015
Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis
Iron-sulfur cluster biogenesis is executed by distinct protein assembly systems. Mammals have two systems, the mitochondrial Fe-S… 
Highly Cited
2013
Highly Cited
2013
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth
Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic… 
2012
2012
BCL2-CISD2
CISD2, an ER BCL2-associated autophagy regulator also known as NAF-1, is responsible for the human degenerative disorder Wolfram… 
Highly Cited
2010
Highly Cited
2010
Crosstalk between apoptosis and autophagy within the Beclin 1 interactome
Although the essential genes for autophagy (Atg) have been identified, the molecular mechanisms through which Atg proteins… 
Highly Cited
2009
Highly Cited
2009
Author ' s personal copy Crystal Structure of Miner 1 : The Redox-active 2 Fe2 S Protein Causative in Wolfram Syndrome 2
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