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Sulfasalazine has been repurposed to induce ferroptotic cancer cell death via inhibition of xc--cystine/glutamate antiporter (xCT… Expand CISD2 is a causative gene associated with Wolfram syndrome (WFS). However, it remains a mystery as to how the loss of CISD2… Expand Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic… Expand To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of… Expand The CISD2 gene, which is an evolutionarily conserved novel gene, encodes a transmembrane protein primarily associated with the… Expand Although the essential genes for autophagy (Atg) have been identified, the molecular mechanisms through which Atg proteins… Expand Human mitoNEET is a homodimeric iron-sulfur protein located in the outer mitochondrial membrane with unknown function, but which… Expand CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Significantly, the CISD2… Expand The endoplasmic reticulum protein Miner1 is essential for health and longevity. Mis-splicing of CISD2, which codes for Miner1, is… Expand A single missense mutation was identified in a novel, highly conserved zinc-finger gene, ZCD2, in three consanguineous families… Expand