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Significant correlation of the SCN1A mutations and severe myoclonic epilepsy in infancy.
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Smoke exposure, histologic type and geography‐related differences in the methylation profiles of non‐small cell lung cancer
TLDR
Important smoke exposure, histologic type and geography‐related differences in the methylation profiles of NSCLC tumors are demonstrated.
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Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
TLDR
The results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.
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Three human transforming genes are related to the viral ras oncogenes.
TLDR
Three distinct transforming genes present in human tumor cell lines are all related to the viral oncogenes of Harvey and Kirsten murine sarcoma viruses, designated v-H-ras and v-K-ras, respectively, and based on the homology with the v-ras genes, they are established to be a third member of the ras gene family, which is called N-ras.
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Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change
TLDR
The H-ras-1 gene cloned from T24 DNA induces transformation in NIH 3T3 cells, while the same gene cloning from normal cellular DNA does not, and the functionally significant difference appears to be a single base mutation.
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Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1
TLDR
A common modular structure for ras gene products in which the variable region forms a physiologically important combining site is proposed.
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Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers
TLDR
R reverse-transcription-PCR analysis demonstrated decreased or no expression of ING3 mRNA in 50% of primary tumors as compared with that of matched normal samples, suggesting a possibility that the ING 3 gene functions as a TSG in a subset of HNSCC.
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HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3.
TLDR
The phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3p21.3, an area frequently deleted in many types of cancer, especially within the functionally defined narrow region.
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NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells.
TLDR
Findings indicate that NOTCH3-mediated signaling rather than NOTCH1- mediated signaling plays an important role in the proliferation of ErbB2-negative breast tumor cells and that targeted suppression of this signaling pathway may be a promising strategy for the treatment of Er bBB 2- negative breast cancers.
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The impact of epidermal growth factor receptor gene status on gefitinib‐treated Japanese patients with non‐small‐cell lung cancer
TLDR
It is suggested that the CA‐SSR1 length may influence the clinical outcome in patients with a drug‐sensitive EGFR mutation and the high EGFR copy number may not be related to clinical benefits in gefitinib‐treated Japanese patients with NSCLC.
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