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CDC42 gene

Known as: GTP-BINDING PROTEIN, 25-KD, G25K, GTP binding protein, 25kDa 
This gene is involved in the regulation of the actin cytoskeleton.
National Institutes of Health

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CDC42 wt Allele
Cell Cycle ControlEndocytosisGTP Bindingcdc42 GTP-Binding Protein

Papers overview

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Highly Cited
2010
Highly Cited
2010
Altered Cortical CDC42 Signaling Pathways in Schizophrenia: Implications for Dendritic Spine Deficits
Highly Cited
2005
Highly Cited
2005
Deleted in Colorectal Cancer Binding Netrin-1 Mediates Cell Substrate Adhesion and Recruits Cdc42, Rac1, Pak1, and N-WASP into an Intracellular Signaling Complex That Promotes Growth Cone Expansion
Extracellular cues direct axon extension by regulating growth cone morphology. The netrin-1 receptor deleted in colorectal cancer… 
Highly Cited
2002
Highly Cited
2002
ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53
The ProSAP/Shank family of multidomain proteins of the postsynaptic density (PSD) can either directly or indirectly interact with… 
Highly Cited
1998
Highly Cited
1998
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
The GTPases Rac and Cdc42Hs control diverse cellular functions. In addition to being mediators of intracellular signaling… 
Highly Cited
1996
Highly Cited
1996
Mammalian Cdc42 Is a Brefeldin A-sensitive Component of the Golgi Apparatus*
In this study, we have used immunocytochemical and fractionation approaches to provide a description of the localization of the… 
Highly Cited
1994
Highly Cited
1994
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.
Highly Cited
1994
Highly Cited
1994
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.
The Ras-like GTPase Cdc42 is essential for cell polarity and bud site assembly in Saccharomyces cerevisiae by regulating cell… 
Review
1993
Review
1993
Emerging concepts in the Ras superfamily of GTP‐binding proteins
The Ras superfamily of GTP‐binding proteins (> 50 members) regulates a diverse spectrum of intracellular processes. These include… 
Highly Cited
1992
Highly Cited
1992
A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs.
Members of the family of Ras-related guanosine triphosphate (GTP) binding proteins appear to take part in the regulation of a… 
Highly Cited
1991
Highly Cited
1991
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product
THE superfamily of low molecular mass GTP-binding proteins, for which the ras proteins are prototypes, has been implicated in the… 
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