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Reactive oxygen species‐induced activation of ERK and p38 MAPK mediates PMA‐induced NETs release from human neutrophils
- R. Keshari, A. Verma, M. Barthwal, M. Dikshit
- Biology, ChemistryJournal of cellular biochemistry
- 1 March 2013
It is demonstrated that ROS dependent activation of ERK and p38 MAPK, which mediated PMA induced NETs release from human neutrophils, was downstream to free radical generation.
Metabolic Insight of Neutrophils in Health and Disease
Recent developments in understanding of the metabolic regulation of neutrophils may provide clues for better management and newer therapeutic opportunities for neutrophil centric immuno-deficiencies and inflammatory disorders.
Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition
Role of IL-1β, TNFα and IL-8 thus seems to be involved in the enhanced release of NETs in SIRS subjects.
Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential
It is demonstrated that NO by augmenting enzymatic free radical generation release NETs to promote extracellular bacterial killing.
Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
Nitric oxide synthase regulation and diversity: implications in Parkinson's disease.
Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation.
Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis.
Nitrite content and antioxidant enzyme levels in the blood of schizophrenia patients
A significant decrease in NO synthesis and an increase in MDA in the PMN of schizophrenia patients is indicated, which suggests that the decrease in PMN NO synthesis by PMN might lead to oxidative stress in schizophrenia patients.