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Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils.
Neutrophils/polymorphonuclear leukocytes (PMNs), an important component of innate immune system, release extracellular traps (NETs) to eliminate invaded pathogens; however understanding of the roleExpand
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Profile of acetylcholinesterase in brain areas of male and female rats of adult and old age.
Inhibition of acetylcholinesterase (AChE)-metabolizing enzyme of acetylcholine, is presently the most important therapeutic target for development of cognitive enhancers. However, AChE activity inExpand
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Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential
Neutrophils expel extracellular traps (NETs) to entrap and exterminate the invaded micro‐organisms. Acute/chronic inflammatory disorders are often observed with aberrantly enhanced NETs formation andExpand
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Piper betle Linn. a maligned Pan-asiatic plant with an array of pharmacological activities and prospects for drug discovery
Piper betle L. is one of the important plants in the Asiatic region which ranks second to coffee and tea in terms of daily consumption. Though the plant is known for abuse, in recent years severalExpand
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Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition
Neutrophils (PMNs) and cytokines have a critical role to play in host defense and systemic inflammatory response syndrome (SIRS). Neutrophil extracellular traps (NETs) have been shown toExpand
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Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
INTRODUCTION Circulating lipopolysaccharides released from bacteria may activate both neutrophils and monocytes. The activated neutrophils release myeloperoxidase (MPO), a specific enzyme with strongExpand
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Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation.
High availability of NO, oxidative stress and neutrophil extracellular trap (NETs) contents are often noticed at the site of inflammation/infection. Studies from this lab and others have reported NOExpand
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Nitric oxide synthase regulation and diversity: implications in Parkinson's disease.
Nitric oxide (NO) is a janus faced chemical messenger, which, in the recent years, has been the focus of neurobiologists for its involvement in neurodegenerative disorders in particular, Parkinson'sExpand
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Modulation of polymorphonuclear leukocytes function by nitric oxide.
Recognition of the endothelium-derived relaxation factor as nitric oxide (NO) gave rise to an impression that NO was synthesised only by the endothelial lining of the vessel wall. Later it was foundExpand
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Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats.
The present investigation was undertaken to suggest the involvement of free radicals in the pathogenesis of pyloric ligation induced ulcers in rats. Lipid peroxidation product (MDA), antioxidantExpand
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