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Characterization of Two Alternately Spliced Forms of Phospholipase D1
An evolutionarily conserved shorter splice variant of PLD1 lacking 38 amino acids is identified that arises from regulated splicing of an alternate exon, suggesting that these three classes of regulators interact with different sites on the enzyme.
Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells.
MiR‐34a attenuates paclitaxel‐resistance of hormone‐refractory prostate cancer PC3 cells through direct and indirect mechanisms
- K. Kojima, Y. Fujita, Y. Nozawa, T. Deguchi, Masafumi Ito
- Medicine, BiologyThe Prostate
- 1 October 2010
This work aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone‐refractory prostate cancer with a special focus on the roles of miR‐34a and SIRT1.
Biochemical and Cell Biological Analyses of a Mammalian Septin Complex, Sept7/9b/11*
- K. Nagata, T. Asano, Y. Nozawa, M. Inagaki
- Biology, ChemistryJournal of Biological Chemistry
- 31 December 2004
Results suggest that septin filament structures may be affected by interactions with other septins included in the septin complex.
Cloning and Disruption of caPLB1, a Phospholipase B Gene Involved in the Pathogenicity of Candida albicans *
Although deletion of caPLB1 did not produce any detectable effects on candidal adherence to human endothelial or epithelial cells, the ability of the caplb1 null mutant to penetrate host cells was dramatically reduced, suggesting phospholipase B may well contribute to the pathogenicity of C. albicans by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.
MicroRNA-141 and -200a Are Involved in Bone Morphogenetic Protein-2-induced Mouse Pre-osteoblast Differentiation by Targeting Distal-less Homeobox 5
It is observed for the first time that miR-141 and -200a are involved in pre-osteoblast differentiation in part by regulating the expression of Dlx5.
Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen
- Y. Akao, Y. Nakagawa, M. Iinuma, Y. Nozawa
- BiologyInternational Journal of Molecular Sciences
- 1 March 2008
A mechanism of α-mangostin-induced growth inhibition in DLD-1 cells is focused on, which could provide a relevant basis for the development of xanthones as an agent for cancer prevention and the combination therapy with anti-cancer drugs.
Evidence implicating phospholipase as a virulence factor of Candida albicans
Results implicate extracellular phospholipase as a virulence factor in the pathogenesis of hematogenous infections caused by C. albicans.
MiR-148a Attenuates Paclitaxel Resistance of Hormone-refractory, Drug-resistant Prostate Cancer PC3 Cells by Regulating MSK1 Expression*
The findings suggest that miR-148a plays multiple roles as a tumor suppressor and can be a promising therapeutic target for hormone-refractory prostate cancer especially for drug-resistant prostate cancer.
Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death
It is suggested that ceramide generated by activation of neutral magnesium-dependent sphingomyelinase mediates hypoxic cell death and that Bcl-2 has inhibitory effects on ceramide formation and caspase activation.