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Characterization of Two Alternately Spliced Forms of Phospholipase D1
  • S. Hammond, J. Jenco, +7 authors Andrew J. Morris
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 7 February 1997
An evolutionarily conserved shorter splice variant of PLD1 lacking 38 amino acids is identified that arises from regulated splicing of an alternate exon, suggesting that these three classes of regulators interact with different sites on the enzyme. Expand
Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells.
Ectopic miR-34a expression resulted in cell cycle arrest and growth inhibition and attenuated chemoresistance to anticancer drug camptothecin by inducing apoptosis, suggesting a potential role of miR -34a for the treatment of p53-defective prostate cancer. Expand
Biochemical and Cell Biological Analyses of a Mammalian Septin Complex, Sept7/9b/11*
Results suggest that septin filament structures may be affected by interactions with other septins included in the septin complex. Expand
Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen
A mechanism of α-mangostin-induced growth inhibition in DLD-1 cells is focused on, which could provide a relevant basis for the development of xanthones as an agent for cancer prevention and the combination therapy with anti-cancer drugs. Expand
Evidence implicating phospholipase as a virulence factor of Candida albicans
Results implicate extracellular phospholipase as a virulence factor in the pathogenesis of hematogenous infections caused by C. albicans. Expand
Cloning and Disruption of caPLB1, a Phospholipase B Gene Involved in the Pathogenicity of Candida albicans *
Although deletion of caPLB1 did not produce any detectable effects on candidal adherence to human endothelial or epithelial cells, the ability of the caplb1 null mutant to penetrate host cells was dramatically reduced, suggesting phospholipase B may well contribute to the pathogenicity of C. albicans by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection. Expand
MicroRNA-141 and -200a Are Involved in Bone Morphogenetic Protein-2-induced Mouse Pre-osteoblast Differentiation by Targeting Distal-less Homeobox 5
It is observed for the first time that miR-141 and -200a are involved in pre-osteoblast differentiation in part by regulating the expression of Dlx5. Expand
MiR‐34a attenuates paclitaxel‐resistance of hormone‐refractory prostate cancer PC3 cells through direct and indirect mechanisms
This work aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone‐refractory prostate cancer with a special focus on the roles of miR‐34a and SIRT1. Expand
Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death
It is suggested that ceramide generated by activation of neutral magnesium-dependent sphingomyelinase mediates hypoxic cell death and that Bcl-2 has inhibitory effects on ceramide formation and caspase activation. Expand
MiR-148a Attenuates Paclitaxel Resistance of Hormone-refractory, Drug-resistant Prostate Cancer PC3 Cells by Regulating MSK1 Expression*
The findings suggest that miR-148a plays multiple roles as a tumor suppressor and can be a promising therapeutic target for hormone-refractory prostate cancer especially for drug-resistant prostate cancer. Expand