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CDC42 wt Allele

Known as: G25K, GP, CDC42Hs 
Human CDC42 wild-type allele is located in the vicinity of 1p36.33 and is approximately 22 kb in length. This allele, which encodes PITSLRE serine… 
National Institutes of Health

Related topics

Related topics

14 relations
1p36.1Agrin PathwayCell Cycle ControlCell Migration Pathway

Broader (1)

CDC42 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Backbone dynamics of an oncogenic mutant of Cdc42Hs shows increased flexibility at the nucleotide-binding site.
Cdc42Hs, a member of the Ras superfamily of GTP-binding signal transduction proteins, binds guanine nucleotides, and acts as a… 
2002
2002
The acidic regions of WASp and N‐WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia
Highly Cited
2001
Highly Cited
2001
Coiling Phagocytosis of Borrelia burgdorferiby Primary Human Macrophages Is Controlled by CDC42Hs and Rac1 and Involves Recruitment of Wiskott-Aldrich Syndrome Protein and Arp2/3 Complex
ABSTRACT Lyme borreliosis is a multisystemic disorder primarily affecting the skin, nervous system, and joints. It is caused by… 
Highly Cited
2000
Highly Cited
2000
Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease – the small G protein may play a role in cholesterol efflux
2000
2000
Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase.
Cdc42Hs is a member of the Ras superfamily of GTPases and initiates a cascade that begins with the activation of several kinases… 
2000
2000
Extinction of Rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway
Apoptosis is a normal physiological process which eliminates cells that do not receive adequate extracellular signals. One of the… 
1996
1996
Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using extrinsic reporter group fluorescence.
The overall goal of these studies was to examine the applicability of extrinsic reporter group fluorescence in monitoring the GTP… 
Highly Cited
1995
Highly Cited
1995
TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.
We have previously shown that the LAZ3/BCL6 gene encoding a potential transcription factor, is disrupted in B-diffuse large cell… 
Highly Cited
1995
Highly Cited
1995
A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils (*)
Cdc42Hs and Rac1 are members of the Ras superfamily of small molecular weight (p21) GTP binding proteins. Cdc42Hs induces… 
Highly Cited
1995
Highly Cited
1995
Characterization of the Effector-specifying Domain of Rac Involved in NADPH Oxidase Activation (*)
Production of microbicidal oxidants by phagocytic leukocytes requires activation of a latent NADPH oxidase by the coordinated… 
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