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CD86 gene

Known as: B-lymphocyte antigen B7-2, CD86 molecule, CD28 ANTIGEN LIGAND 2 
This gene plays a role in the modulation of T-cell proliferation and interleukin production.
National Institutes of Health

Related topics

Related topics

5 relations
CD86 AntigenSignal TransductionT-Cell ProliferationT-Lymphocyte Activation Antigen CD86

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CD86 wt Allele

Papers overview

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Highly Cited
2004
Highly Cited
2004
Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors.
Highly Cited
1999
Highly Cited
1999
The role of CTLA-4 in regulating Th2 differentiation.
To examine the role of CTLA-4 in Th cell differentiation, we used two newly generated CTLA-4-deficient (CTLA-4-/-) mouse strains… 
Highly Cited
1999
Highly Cited
1999
4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine.
A20 is a B cell lymphoma that constitutively expresses the costimulatory molecule B7-2 yet grows readily as a tumor in syngeneic… 
Highly Cited
1998
Highly Cited
1998
Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells
Peripheral tolerance mechanisms normally prevent delivery of T cell help to anergic self-reactive B cells that accumulate in the… 
Highly Cited
1997
Highly Cited
1997
The mucosal adjuvanticity of cholera toxin involves enhancement of costimulatory activity by selective up-regulation of B7.2 expression.
Cholera toxin (CT) is a potent mucosal immunogen and adjuvant that can strongly prime mucosal T cells. The present study was… 
Highly Cited
1997
Highly Cited
1997
Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD)
The molecules B7.1 and B7.2 deliver costimulatory signals of critical importance to naive T cells, and may thus be involved in… 
Highly Cited
1995
Highly Cited
1995
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.
Highly Cited
1995
Highly Cited
1995
Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule
Blockade of the interactions between CD28/CTLA‐4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), seems an attractive means… 
Highly Cited
1995
Highly Cited
1995
CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4+ T cells and induce similar patterns of cytokine secretion in vitro.
The interaction of CD28 and its ligands is critical for antigen-induced T cell activation. Recent studies have demonstrated the… 
Highly Cited
1995
Highly Cited
1995
Localization in situ of the co‐stimulatory molecules B7.1, B7.2, CD40 and their ligands in normal human lymphoid tissue
Functional interactions between B and T lymphocytes are known to depend on the expression of co‐stimulatory molecules B7.1/CD80… 
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