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CD86 gene

Known as: B-lymphocyte antigen B7-2, CD86 molecule, CD28 ANTIGEN LIGAND 2 
This gene plays a role in the modulation of T-cell proliferation and interleukin production.
National Institutes of Health

Related topics

Related topics

5 relations
CD86 AntigenSignal TransductionT-Cell ProliferationT-Lymphocyte Activation Antigen CD86

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CD86 wt Allele

Papers overview

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2003
2003
Unique Regulation Profile of Prostaglandin E1 on Adhesion Molecule Expression and Cytokine Production in Human Peripheral Blood Mononuclear Cells
In the present study, we examined the effects of prostaglandin E1 (PGE1) on the expression of intercellular adhesion molecule… 
Highly Cited
2000
Highly Cited
2000
B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness.
We examined the roles of B7-1 (CD80) and B7-2 (CD86) in a model of allergic pulmonary inflammation and airway hyperresponsiveness… 
2000
2000
VIP and PACAP Induce Shift to a Th2 Response by Upregulating B7.2 Expression
Abstract: VIP and PACAP, two structurally related neuropeptides produced within the lymphoid microenvironment, modulate several… 
Highly Cited
1999
Highly Cited
1999
B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.
Costimulatory molecules, termed B7.1 and B7.2, are present on the surfaces of APC and are important for the activation of T… 
Highly Cited
1999
Highly Cited
1999
B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance.
Oral administration of Ag leads to systemic unresponsiveness (oral tolerance) to the fed Ag. Oral tolerance is mediated through… 
1999
1999
B7.2 has opposing roles during the activation versus effector stages of experimental autoimmune thyroiditis.
APCs provide costimulatory and down-regulatory signals to Ag-activated T cells through interactions between B7.1 and B7.2 on APCs… 
Highly Cited
1996
Highly Cited
1996
IFN-alpha induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7.2.
Insulin-dependent diabetes is an autoimmune disease characterized by the loss of the insulin-producing beta cells and the… 
Highly Cited
1996
Highly Cited
1996
Brucella abortus as a potential vaccine candidate: induction of interleukin-12 secretion and enhanced B7.1 and B7.2 and intercellular adhesion molecule 1 surface expression in elutriated human…
Development of a vaccine which is capable of generating a strong cellular immune response associated with gamma interferon (IFN… 
1996
1996
Comparison of CD28‐B7.1 and B7.2 functional interaction in resting human T cells: Phosphatidylinositol 3‐kinase association to CD28 and cytokine production
CD28 is a 44‐kDa homodimer present on T cells providing an important costimulatory signal for T cell proliferation, cytokine… 
1995
1995
Activation of murine T cells by bacterial superantigens requires B7-mediated costimulation.
Staphylococcus enterotoxins bind class II MHC molecules on antigen-presenting cells (APC) and stimulate T cells expressing… 
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