• Publications
  • Influence
Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
Post-ischemic inflammation is an essential step in the progression of brain ischemia-reperfusion injury. However, the mechanism that activates infiltrating macrophages in the ischemic brain remainsExpand
  • 277
  • 12
  • PDF
Karyotypic evolution in the Galliformes: An examination of the process of karyotypic evolution by comparison of the molecular cytogenetic findings with the molecular phylogeny
To define the process of karyotypic evolution in the Galliformes on a molecular basis, we conducted genome-wide comparative chromosome painting for eight species, i.e. silver pheasant (LophuraExpand
  • 98
  • 11
Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats
Background and Purpose— High mobility group box-1 (HMGB1) exhibits inflammatory cytokine-like activity in the extracellular space. We previously demonstrated that intravenous injection of anti-HMGB1Expand
  • 213
  • 9
  • PDF
Anti‐high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats
The high mobility group box‐1 (HMGB1), originally identified as an architectural nuclear protein, exhibits an inflammatory cytokine‐like activity in the extracellular space. Here we show thatExpand
  • 300
  • 7
  • PDF
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.
In mammals, histamine action is terminated through metabolic inactivation by histamine N-methyltransferase (HNMT) and diamine oxidase. In addition to three well-studied pharmacological functions,Expand
  • 55
  • 6
High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice
Objective—High-mobility group box protein 1 (HMGB1) is a DNA-binding protein and cytokine highly expressed in atherosclerotic lesions, but its pathophysiological role in atherosclerosis is unknown.Expand
  • 115
  • 5
  • PDF
Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140).
We recently reported the characterization of a platelet granule membrane protein of molecular weight (mol wt) 40,000 called granulophysin (Gerrard et al: Blood 77:101, 1991), identified by aExpand
  • 101
  • 5
  • PDF
E-Prostanoid (EP)2/EP4 Receptor-Dependent Maturation of Human Monocyte-Derived Dendritic Cells and Induction of Helper T2 Polarization
Prostaglandin (PG) E2 induces dendritic cell maturation in cooperation with proinflammatory cytokines [such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β]. To clarify the involvement ofExpand
  • 38
  • 5
Gene expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1)in human osteoarthritic cartilage.
We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade ofExpand
  • 31
  • 5
  • PDF
Characterization of Histamine Release from the Rat Hypothalamus as Measured by In Vivo Microdialysis
Abstract: The release of endogenous histamine (HA) from the hypothalamus of anesthetized rats was measured by in vivo microdialysis coupled with HPLC with fluorescence detection. Freshly preparedExpand
  • 113
  • 4