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CD46 Antigen

Known as: Trophoblast Leukocyte Common Antigen, membrane cofactor protein (MCP), CD46 Antigens 
A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a cofactor for their inactivation. CD46 also… 
National Institutes of Health

Related topics

Related topics

13 relations
Actin-Binding ProteinCD46 geneIn BloodProcess of secretion

Broader (2)

CD AntigensImmunologic Factors

Narrower (1)

CD46 protein, human

Papers overview

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Review
2006
Review
2006
Self, non-self, and danger: a complementary view.
Complement is a sophisticated system of molecules that is critical to the functional integrity of the body. Initially considered… 
Highly Cited
2004
Highly Cited
2004
Measles Virus (MV) Hemagglutinin: Evidence that Attachment Sites for MV Receptors SLAM and CD46 Overlap on the Globular Head
ABSTRACT Measles virus hemagglutinin (MVH) residues potentially responsible for attachment to the wild-type (wt) MV receptor SLAM… 
Review
2002
Review
2002
RNA viruses as virotherapy agents
RNA viruses are rapidly emerging as extraordinarily promising agents for oncolytic virotherapy. Integral to the lifecycles of all… 
Highly Cited
1996
Highly Cited
1996
Susceptibility of HIV-1 plasma virus to complement-mediated lysis. Evidence for a role in clearance of virus in vivo.
This study was undertaken to directly assess the susceptibility of HIV-1 plasma virus to C-mediated lysis. Plasma from HIV… 
Highly Cited
1996
Highly Cited
1996
Mapping amino acids of the measles virus hemagglutinin responsible for receptor (CD46) downregulation.
We compared the amino acid sequences of groups of receptor (CD46) downregulating and nondownregulating measles virus (MV… 
Highly Cited
1996
Highly Cited
1996
Complement Regulatory Molecules on Human Myelin and Glial Cells: Differential Expression Affects the Deposition of Activated Complement Proteins
Abstract: The expression of decay‐accelerating factor CD55, membrane cofactor protein CD46, and CD59 was studied on Schwann cells… 
Highly Cited
1995
Highly Cited
1995
Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46 (*)
The complement system membrane cofactor protein (MCP) CD46 serves as a C3b/C4b inactivating factor for the protection of host… 
Highly Cited
1994
Highly Cited
1994
EFFECTS OF TRANSFECTED COMPLEMENT REGULATORY PROTEINS, MCP, DAF, AND MCP/DAF HYBRID, ON COMPLEMENT‐MEDIATED SWINE ENDOTHELIAL CELL LYSIS
We established several swine endothelial cell (SEC) lines, expressing human MCP (CD46), DAF (CD55), and MCP/DAF hybrid by… 
Highly Cited
1992
Highly Cited
1992
Tissue‐specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing
CD46 (membrane cofactor protein) is a human cell surface glycoprotein withcofactoractivity for factor I‐mediated cleavage of… 
Highly Cited
1991
Highly Cited
1991
Phospholipid-anchored and transmembrane versions of either decay- accelerating factor or membrane cofactor protein show equal efficiency in protection from complement-mediated cell damage
Decay-accelerating factor (DAF) is a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein that protects cells from… 
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