• Publications
  • Influence
Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae
TLDR
Mapping of the requirement for partitioning into Caveolae demonstrated that the amino-terminal sequence Met-Gly-Cys is both necessary and sufficient within the context of a Src family PTK to confer localization into caveolae.
Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette.
TLDR
It is shown that phosphorylation of caveolin-1 on tyrosine 14 confers binding to Grb7 (an SH2-domain containing protein) both in vitro and in vivo, and it is demonstrated that binding ofgrb7 to tyrosin 14-phosphorylated caveolin -1 functionally augments anchorage-independent growth and epidermal growth factor-stimulated cell migration.
Coxsackievirus B3 adapted to growth in RD cells binds to decay-accelerating factor (CD55)
TLDR
The results indicate that growth of CB3 in RD cells selected for a virus strain that uses DAF for cell surface attachment, which is the complement regulatory protein, decay-accelerating factor (DAF) (CD55).
Critical properties of the two-dimensional XY model
The critical properties of the xy model with nearest-neighbour interactions on a two-dimensional square lattice are studied by a renormalization group technique. The mean magnetization is zero for
Accumulation of Caveolin in the Endoplasmic Reticulum Redirects the Protein to Lipid Storage Droplets
TLDR
The data suggest that accumulation of caveolin-1 to unusually high levels in the ER causes targeting to lipid droplets, and that mechanisms must exist to ensure the rapid exit of newly synthesized caveolae from the ER to avoid this fate.
Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic
TLDR
These findings bring the traditionally extracellular E. coli into the realm of opportunistic intracellular parasitism and suggest how opportunistic infections with FimH-expressing enterobacteria could occur in a setting deprived of opsonizing antibodies.
CD36 Is Palmitoylated on Both N- and C-terminal Cytoplasmic Tails*
TLDR
It is confirmed that human CD36 is palmitoylated and identified cysteines 3, 7, 464, and 466 as the palMIToylation sites using a mutagenesis approach, which suggests that both the N- and C-terminal tails of CD36 are cytoplasmic.
Caveolin Is Palmitoylated on Multiple Cysteine Residues
TLDR
It is reported that caveolin, an integral membrane protein which forms part of the coat of caveolae, also incorporates palmitate through linkage to cysteine residues.
Palmitoylation of Caveolin-1 at a Single Site (Cys-156) Controls Its Coupling to the c-Src Tyrosine Kinase
TLDR
A series of novel lipid-lipid-based interactions as important regulatory factors for coupling caveolin-1 to the c-Src tyrosine kinase in vivo are identified, which are both myristoylation-dependent and sequence-specific.
Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.
Cross-linking of glycosyl-phosphatidylinositol (GPI)-anchored membrane proteins on T cells can trigger cell activation. We and others have shown an association between GPI-anchored proteins and the
...
1
2
3
4
5
...