RNA viruses as virotherapy agents

  title={RNA viruses as virotherapy agents},
  author={Stephen Russell},
  journal={Cancer Gene Therapy},
RNA viruses are rapidly emerging as extraordinarily promising agents for oncolytic virotherapy. Integral to the lifecycles of all RNA viruses is the formation of double-stranded RNA, which activates a spectrum of cellular defense mechanisms including the activation of PKR and the release of interferon. Tumors are frequently defective in their PKR signaling and interferon response pathways, and therefore provide a relatively permissive substrate for the propagation of RNA viruses. For most of… CONTINUE READING


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A genetically engineered influenza A virus with ras -dependent oncolytic properties

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