Benzodiazepine Receptor

TSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral tissue binding sites for benzodiazepines… Expand

The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely distributed transmembrane protein that is… Expand

Benzodiazepines (BZs)2 are used clinically as muscle relaxants, anticonvulsants, anxiolytics, and sedative-hypnotics. These… Expand

NEUROTRANSMISSION effected by GABA (γ-aminobutyric acid) is predominantly mediated by a gated chloride channel intrinsic to the… Expand

We have investigated the subcellular localization of the peripheral-type benzodiazepine receptor in rat adrenal gland using the… Expand

Benzodiazepines produce most, if not all, of their numerous effects on the central nervous system (CNS) primarily by increasing… Expand

Investigation of the actions of the benzodiazepines has provided insights into the neurochemical mechanisms underlying anxiety… Expand

Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in… Expand

[3H]Diazepam appears to bind specifically to a single, saturable, binding site located on rat brain membranes, with an affinity… Expand

HIGH affinity binding of tritium labelled morphine and morphine-like drugs to membranes in brain homogenates1–3 was a decisive… Expand