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Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography.

The biodistribution of 3H-PK 11195, an antagonist of the peripheral-type benzodiazepine receptors, was studied in mice and radioactivity in the heart, lung, spleen, kidney and adrenal was significantly decreased by the coadministration of carrier PK 11 195, which indicated that PK 11195 specifically binds to the receptors.
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Cobalt chelate of bleomycin. I. Physicochemical properties and distribution in tumor bearing mice.

From these results, it is concluded Co-BLM to be superior as a tumor scanning agent than BLM and other BLM metal chelates.
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Synthesis and evaluation of11C-PK 11195 forin vivo study of peripheral-type benzodiazepine receptors using position emission tomography

The biodistribution of3H-PK 11195, an antagonist of the peripheral-type benzodiazepine receptors, was studied in mice and radioactivity in the heart, lung, spleen, kidney and adrenal was significantly decreased by the coadministration of carrier PK 11 195, which indicated that PK 11195 specifically binds to the receptors.
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2‐Deoxy‐2‐Fluoro‐d‐Glucose as a Functional Probe for NMR: The Unique Metabolism Beyond Its 6‐Phosphate

The fundamental NMR properties of metabolites, spectral assignments, and reliability of NMR quantification were studied and FDG uptake in mouse brain was shown to be in the range of interpretation using the biochemical parameters of enzymes for glucose uptake as long as a dose of <200 mg/kg was used.
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A new synthesis of 2‐deoxy‐2‐[18f]fluoro‐D‐galactose using [18f]fluoride ion

A nucleophilic radiofluorination of methyl 3,4-0-isopropylidene-2-0-(trifluoromethanesulfonyl)-6-0-trityl-β-D- talopyranoside (1) with aminopolyether (Kryptofix 2.2.2.) supported potassium…
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New adrenal-scanning agent.

A new adrenal-specific compound, 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol(NCL-3-I), which is derived from 19-iodocholesterol (CL-19-I), has been found. Tissue distribution studies have…
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Syntheses OF 15α- and 15β-carboxymethyltestosterone bovine serum albumin conjugates: Characteristics of the antisera to testosterone

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Tissue distribution of radioiodinated Ricinus lectins

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Homoallylic rearrangement of 19-iodocholest-5-en-3β-ol: New adrenal scanning agent

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Tumor scanning with 57Co-Bleomycin

A preliminary study on the use of 57Co-Bleomycin for the diagnosis of malignant tumor, one of antitumor antibiotics discovered by Umezawa and his collaborators is presented.
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