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Basic Helix-Loop-Helix Transcription Factors

Known as: bHLH Transcription Factors, Basic HLH Protein, BHLH Protein 
bHLH class proteins are sequence-specific DNA-binding proteins that contain a conserved 50-amino acid HLH domain consisting of two alpha-helices… 
National Institutes of Health

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Papers overview

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2009
2009
Phylogenetic Analysis of Zebrafish Basic Helix-Loop-Helix Transcription Factors
The basic helix-loop-helix (bHLH) proteins play important regulatory roles in eukaryotic developmental processes including… 
Highly Cited
2006
Highly Cited
2006
Interaction of bHLH-PAS proteins involved in juvenile hormone reception in Drosophila.
Highly Cited
2002
Highly Cited
2002
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein…
Under low oxygen tension, cells increase the transcription of specific genes involved in angiogenesis, erythropoiesis, and… 
2002
2002
Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor.
The genes encoding basic helix-loop-helix (bHLH) transcription factors have been implicated in many aspects of neural development… 
2000
2000
A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors.
Calmodulin is the predominant intracellular receptor for Ca(2+) signals, mediating the regulation of numerous cellular processes… 
Review
1998
Review
1998
Calcium regulation of basic helix-loop-helix transcription factors.
Highly Cited
1996
Highly Cited
1996
The GAP-43 Gene Is a Direct Downstream Target of the Basic Helix-Loop-Helix Transcription Factors*
The GAP-43 promoter region contains seven E-boxes (E1 to E7) that are organized in two clusters, a distal cluster (E3 to E7) and… 
Highly Cited
1996
Highly Cited
1996
The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1 alpha and Drosophila single-minded.
Highly Cited
1994
Highly Cited
1994
Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.
Highly Cited
1994
Highly Cited
1994
Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins
Tumor-specific activation of the TAL1 gene is the most common genetic alteration seen in patients with T-cell acute lymphoblastic… 
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