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Basic Helix-Loop-Helix Transcription Factors

Known as: bHLH Transcription Factors, Basic HLH Protein, BHLH Protein 
bHLH class proteins are sequence-specific DNA-binding proteins that contain a conserved 50-amino acid HLH domain consisting of two alpha-helices… 
National Institutes of Health

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Papers overview

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Highly Cited
2004
Highly Cited
2004
Highly specific interactions between bHLH transcription factors and chromatin during retina development
Basic helix-loop-helix (bHLH) transcription factors such as atonal homolog 5 (ATH5) and neurogenin 2 (NGN2) determine crucial… 
2000
2000
A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors.
Calmodulin is the predominant intracellular receptor for Ca(2+) signals, mediating the regulation of numerous cellular processes… 
Highly Cited
1999
Highly Cited
1999
Gene expression pattern Characterization of Npas 3 , a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system
Here we describe the cloning and expression pattern of a new bHLH-PAS domain gene, Npas3. Npas3 shares 50.2% amino acid sequence… 
1999
1999
A transcription factor involved in skeletal muscle gene expression is deleted in patients with Williams syndrome
Williams-Beuren syndrome (WS) is a developmental disorder caused by a hemizygous microdeletion of approximately 1.4 MB at… 
Highly Cited
1998
Highly Cited
1998
Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric complex of two basic-helix-loop-helix proteins of the PAS family which is… 
Review
1998
Review
1998
Calcium regulation of basic helix-loop-helix transcription factors.
1998
1998
Identification of a Highly Conserved Module in E Proteins Required for in Vivo Helix-loop-helix Dimerization*
Basic helix-loop-helix (bHLH) transcription factors often function as heterodimeric complexes consisting of a tissue-specific… 
1996
1996
Attenuated function of a variant form of the helix‐loop‐helix protein, Id‐3, generated by an alternative splicing mechanism
1993
1993
DNA binding by N- and L-Myc proteins.
N- and L-Myc, like c-Myc, contain adjacent basic region (BR), helix-loop-helix (HLH) and leucine zipper (LZ) motifs, which… 
Review
1992
Review
1992
Activation of muscle-specific transcription by myogenic helix-loop-helix proteins.
Myogenin is a muscle-specific transcription factor that acts as a molecular switch to induce myogenesis. Myogenin shares homology… 
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