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SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.
During the earliest stages of Caenorhabditis elegans embryogenesis, the transcription factor SKN-1 initiates development of the digestive system and other mesendodermal tissues. Postembryonic SKN-1… Expand
MK2‐induced tristetraprolin:14‐3‐3 complexes prevent stress granule association and ARE‐mRNA decay
Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation initiation complexes accumulate in cells subjected to environmental stress. SG‐associated proteins such as TIA‐1, TIAR… Expand
Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans
Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and longevity, effects that… Expand
The myoD gene family: nodal point during specification of the muscle cell lineage.
The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for… Expand
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
The evolutionarily conserved p38 mitogen-activated protein kinase (MAPK) cascade is an integral part of the response to a variety of environmental stresses. Here we show that the Caenorhabditis… Expand
Sequence-specific DNA binding by the c-Myc protein.
- T. Blackwell, L. Kretzner, E. Blackwood, R. Eisenman, H. Weintraub
- Biology, Medicine
- 23 November 1990
While it has been known for some time that the c-Myc protein binds to random DNA sequences, no sequence-specific binding activity has been detected. At its carboxyl terminus, c-Myc contains a… Expand
Quantifying changes in the thiol redox proteome upon oxidative stress in vivo
- L. Leichert, Florian Gehrke, +6 authors U. Jakob
- Biology, Chemistry
- Proceedings of the National Academy of Sciences
- 17 June 2008
Antimicrobial levels of reactive oxygen species (ROS) are produced by the mammalian host defense to kill invading bacteria and limit bacterial colonization. One main in vivo target of ROS is the… Expand
Condition‐adapted stress and longevity gene regulation by Caenorhabditis elegans SKN‐1/Nrf
- Riva de Paula Oliveira, Jess Porter Abate, +4 authors T. Blackwell
- Biology, Medicine
- Aging cell
- 1 October 2009
Studies in model organisms have identified regulatory processes that profoundly influence aging, many of which modulate resistance against environmental or metabolic stresses. In Caenorhabditis… Expand
A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span
Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. Here, we demonstrate that the protein… Expand
Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection.
A technique was developed for studying protein-DNA recognition that can be applied to any purified protein, partially purified protein, or cloned gene. From oligonucleotides in which particular… Expand