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ASCL1 protein, human

Known as: Human Achaete-Scute Homolog 1 Protein, bHLHa46, Class A Basic Helix-Loop-Helix Protein 46 
Achaete-scute homolog 1 (236 aa, ~25 kDa) is encoded by the human ASCL1 gene. This protein plays a role in both transcriptional regulation and signal… 
National Institutes of Health

Related topics

Related topics

15 relations
ACSL1 GeneASCL1 GeneASCL1 wt AlleleCell Differentiation process

Broader (1)

Basic Helix-Loop-Helix Transcription Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
SDF-1/CXCR4 Signaling Maintains Stemness Signature in Mouse Neural Stem/Progenitor Cells
SDF-1 and its primary receptor, CXCR4, are highly expressed in the embryonic central nervous system (CNS) and play a crucial role… 
Highly Cited
2012
Highly Cited
2012
MiR-34a Represses Numbl in Murine Neural Progenitor Cells and Antagonizes Neuronal Differentiation
MicroRNA (miRNA) function is required for normal animal development, in particular in differentiation pathways from stem cell and… 
Highly Cited
2008
Highly Cited
2008
Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells.
Medullary thyroid carcinoma (MTC) is a neuroendocrine (NE) malignancy that frequently metastasizes and has limited treatments. We… 
Highly Cited
2004
Highly Cited
2004
Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.
2004
2004
Transplantation of motoneurons derived from MASH1-transfected mouse ES cells reconstitutes neural networks and improves motor function in hemiplegic mice
Highly Cited
2003
Highly Cited
2003
The role of human achaete-scute homolog-1 in medullary thyroid cancer cells.
Highly Cited
1997
Highly Cited
1997
Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions.
Malignancies with neuroendocrine (NE) features such as medullary thyroid cancer (MTC) and small cell lung cancer (SCLC) are… 
1996
1996
Functional and Physical Interactions between Mammalian Achaete-Scute Homolog 1 and Myocyte Enhancer Factor 2A*
The mammalian achaete-scute homolog 1 (MASH1) protein is required for the early development of the nervous system. However, the… 
Highly Cited
1996
Highly Cited
1996
Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1.
Highly Cited
1993
Highly Cited
1993
XASH1, a Xenopus homolog of achaete-scute: a proneural gene in anterior regions of the vertebrate CNS
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