ASCL1 protein, human

Known as: Human Achaete-Scute Homolog 1 Protein, bHLHa46, Class A Basic Helix-Loop-Helix Protein 46 
Achaete-scute homolog 1 (236 aa, ~25 kDa) is encoded by the human ASCL1 gene. This protein plays a role in both transcriptional regulation and signal… (More)
National Institutes of Health

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ACSL1 GeneASCL1 GeneASCL1 wt AlleleCell Differentiation process
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Broader (1)

Basic Helix-Loop-Helix Transcription Factors

Papers overview

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Highly Cited
2011
Highly Cited
2011
A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.
Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal differentiation when expressed in neural… (More)
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Highly Cited
2007
Highly Cited
2007
Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord.
The neural basic helix-loop-helix transcription factor Ascl1 (previously Mash1) is present in ventricular zone cells in… (More)
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Highly Cited
2007
Highly Cited
2007
Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone.
The subventricular zone (SVZ) is the largest germinal zone in the mature rodent brain, and it continuously produces young neurons… (More)
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Highly Cited
2006
Highly Cited
2006
Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons
Sensory information from the periphery is integrated and transduced by excitatory and inhibitory interneurons in the dorsal… (More)
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Highly Cited
2004
Highly Cited
2004
Ascl1/Mash1 is required for the development of central serotonergic neurons
The transcriptional control of the differentiation of central serotonergic (5-HT) neurons in vertebrates has recently come under… (More)
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Highly Cited
2001
Highly Cited
2001
Crossinhibitory Activities of Ngn1 and Math1 Allow Specification of Distinct Dorsal Interneurons
Distinct classes of neurons are generated from progenitor cells distributed in characteristic dorsoventral patterns in the… (More)
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Highly Cited
2001
Highly Cited
2001
Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord.
Recent studies have demonstrated that neural stem cells and other progenitors are present in the adult CNS. Details of their… (More)
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Highly Cited
2001
Highly Cited
2001
Roles of homeobox and bHLH genes in specification of a retinal cell type.
Previous analysis of mutant mice has revealed that the bHLH genes Mash1 and Math3, and the homeobox gene Chx10 are essential for… (More)
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Highly Cited
1998
Highly Cited
1998
Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system.
Mash1, a mammalian homologue of the Drosophila proneural genes of the achaete-scute complex, is transiently expressed throughout… (More)
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Highly Cited
1997
Highly Cited
1997
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.
The achaete-scute genes encode essential transcription factors in normal Drosophila and vertebrate nervous system development… (More)
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