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ASCL1 protein, human

Known as: Human Achaete-Scute Homolog 1 Protein, bHLHa46, Class A Basic Helix-Loop-Helix Protein 46 
Achaete-scute homolog 1 (236 aa, ~25 kDa) is encoded by the human ASCL1 gene. This protein plays a role in both transcriptional regulation and signal… Expand
National Institutes of Health

Related topics

Related topics

15 relations
ACSL1 GeneASCL1 GeneASCL1 wt AlleleCell Differentiation process
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Broader (1)

Basic Helix-Loop-Helix Transcription Factors

Papers overview

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Highly Cited
2001
Highly Cited
2001
Neural bHLH Genes Control the Neuronal versus Glial Fate Decision in Cortical Progenitors
We have addressed the role of the proneural bHLH genes Neurogenin2 (Ngn2) and Mash1 in the selection of neuronal and glial fates… Expand
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Highly Cited
2001
Highly Cited
2001
Notch signaling induces cell cycle arrest in small cell lung cancer cells.
Among the various forms of human lung cancer, small cell lung cancer (SCLC) exhibits a characteristic neuroendocrine (NE… Expand
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Highly Cited
2000
Highly Cited
2000
A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons.
Neurogenin1 (Ngn1), Neurogenin2 (Ngn2), and Mash1 encode bHLH transcription factors with neuronal determination functions. In the… Expand
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Highly Cited
2000
Highly Cited
2000
Generation of neurons by transient expression of neural bHLH proteins in mammalian cells.
Basic helix-loop-helix (bHLH) transcription factors are known to function during mammalian neurogenesis. Here we show that… Expand
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Highly Cited
1999
Highly Cited
1999
Mash1 regulates neurogenesis in the ventral telencephalon.
Previous studies have shown that mice mutant for the gene Mash1 display severe neuronal losses in the olfactory epithelium and… Expand
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Highly Cited
1998
Highly Cited
1998
MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity.
We have investigated the genetic circuitry underlying the determination of neuronal identity, using mammalian peripheral… Expand
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Highly Cited
1996
Highly Cited
1996
Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members
How growth factors influence the fate of multipotent progenitor cells is not well understood. Most hematopoietic growth factors… Expand
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Highly Cited
1993
Highly Cited
1993
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed… Expand
Highly Cited
1992
Highly Cited
1992
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.
We report the molecular characterization of two novel rat helix-loop-helix (HLH) proteins, designated HES-1 and HES-3, that show… Expand
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Highly Cited
1991
Highly Cited
1991
Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells.
Using monoclonal antibodies, we have examined the expression pattern of MASH1, a basic helix-loop-helix protein that is a… Expand
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