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Specification of the vertebrate eye by a network of eye field transcription factors
TLDR
The results support a model of progressive tissue specification in which neural induction then Otx2-driven neural patterning primes the anterior neural plate for eye field formation and form a self-regulating feedback network that specifies the vertebrate eye field.
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A critical window for cooperation and competition among developing retinotectal synapses
TLDR
Both the initial synaptic strength and the temporal order of activation are critical for heterosynaptic interactions among convergent synaptic inputs during activity-dependent refinement of developing neural networks.
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Conditioned behavior in Drosophila melanogaster.
Populations of Drosophila were trained by alternately exposing them to two odorants, one coupled with electric shock. On testing, the flies avoided the shock-associated odor. Pseudoconditioning,…
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Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos
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Xotch, the Xenopus homolog of Drosophila notch.
TLDR
A Xenopus molecule is identified, Xotch, which is remarkably similar to Drosophila Notch in both structure and developmental expression, and is investigated to investigate whether cell-cell interactions in vertebrate embryos also depend on Notch-like molecules.
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Polarization and orientation of retinal ganglion cells in vivo
TLDR
Four-dimensional microscopy of developing retinal ganglion cells (RGCs) in live zebrafish embryos indicates that extrinsic factors such as access to the basal lamina are critical for normal axon emergence from RGCs in vivo.
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[Development of the nervous system].
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Neuronal determination without cell division in xenopus embryos
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Xotch inhibits cell differentiation in the xenopus retina
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The genetic sequence of retinal development in the ciliary margin of the Xenopus eye.
TLDR
A spatial ordering of gene expression is predicted that predicts a genetic hierarchy governing vertebrate retinogenesis, corroborating some of the relationships between genes predicted to act sequentially.
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