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Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
Summary: We have used a Prx1 limb enhancer to drive expression of Cre Recombinase in transgenic mice. This regulatory element leads to Cre expression throughout the early limb bud mesenchyme and in a…
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression…
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Transient Regenerative Potential of the Neonatal Mouse Heart
It is found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age, which means that for a brief period after birth, the mammalian heart appears to have the capacity to regenerate.
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Using fibre-type-specific promoters, it is shown in cultured muscle cells that PGC-1 alpha activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression.
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Using fibre-type-specific promoters, it is shown in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression.
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis.
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
To address the role of FGFR2 in normal bone development, a conditional gene deletion approach was adopted and robust expression of CRE in mesenchymal condensations giving rise to both osteoblast and chondrocyte lineages.
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
- E. van Rooij, L. Sutherland, E. Olson
- Biology, MedicineProceedings of the National Academy of Sciences
- 2 September 2008
It is concluded that miR-29 acts as a regulator of cardiac fibrosis and represents a potential therapeutic target for tissue fibrosis in general.