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BIRC3 gene

Known as: HIAP1, c-IAP2, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3 
This anti-apoptotic gene regulates apoptotic activity. BIRC3 gene promotes tumor cell survival.
National Institutes of Health

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Related topics

6 relations
ApoptosisBIRC3 protein, humanInhibitor of Apoptosis 1 ProteinNegative Regulation of Apoptosis

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BIRC3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade: A Systematic Review and Meta-analysis.
Importance PD-L1 (programmed cell death ligand 1) immunohistochemistry (IHC), tumor mutational burden (TMB), gene expression… 
Highly Cited
2014
Highly Cited
2014
Recurrent mutations refine prognosis in chronic lymphocytic leukemia
Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3490 patients with CLL for… 
Highly Cited
2011
Highly Cited
2011
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia.
The genetic lesions identified to date do not fully recapitulate the molecular pathogenesis of chronic lymphocytic leukemia (CLL… 
Highly Cited
2011
Highly Cited
2011
Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma.
Splenic marginal zone lymphoma (SMZL) is one of the few B-cell lymphoma types that remain orphan of molecular lesions in cancer… 
Highly Cited
2011
Highly Cited
2011
Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization*
The inhibitor of apoptosis (IAP) proteins are important ubiquitin E3 ligases that regulate cell survival and oncogenesis. The… 
Highly Cited
2010
Highly Cited
2010
Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Highly Cited
2008
Highly Cited
2008
Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment*
Inhibitor of apoptosis (IAP) proteins are key negative regulators of cell death that are highly expressed in many cancers. Cell… 
Highly Cited
2002
Highly Cited
2002
Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis*
We have shown that carbon monoxide (CO) generated by heme oxygenase-1 (HO-1) protects endothelial cells (EC) from tumor necrosis… 
Highly Cited
2001
Highly Cited
2001
Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant.
Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical for normal hematopoiesis. Substitution of valine… 
Highly Cited
2000
Highly Cited
2000
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.
The inhibitor of apoptosis, cIAP2, contains a putative Ring finger motif at the C terminus. Using in vitro ubiquitination assays… 
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