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BIRC2 wt Allele

Known as: MIHB, API1, Mammalian IAP Homolog B 
Human BIRC2 wild-type allele is located in the vicinity of 11q22 and is approximately 30 kb in length. This allele, which encodes baculoviral IAP… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
A better understanding of the mechanisms through which anticancer drugs exert their effects is essential to improve combination… Expand
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Highly Cited
2011
Highly Cited
2011
Three members of the IAP family (X-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis proteins-1/-2 (cIAP1 and… Expand
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Highly Cited
2008
Highly Cited
2008
The inhibitor of apoptosis (IAP) family of proteins enhances cell survival through mechanisms that remain uncertain. In this… Expand
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Highly Cited
2008
Highly Cited
2008
The cellular inhibitor of apoptosis 1 and 2 (cIAP1 and cIAP2) proteins have been implicated in the activation of NF-κB by TNF… Expand
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Highly Cited
2008
Highly Cited
2008
The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative nuclear factor-κB (NF-κB) signaling in… Expand
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Highly Cited
2007
Highly Cited
2007
XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be relieved by IAP antagonists, such as… Expand
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Highly Cited
2007
Highly Cited
2007
Integrity of the blood vessel wall is essential for vascular homeostasis and organ function. A dynamic balance between… Expand
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Highly Cited
2006
Highly Cited
2006
The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through… Expand
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Review
2000
Review
2000
ABSTRACTIAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins… Expand
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Highly Cited
1998
Highly Cited
1998
Inhibitor of apoptosis (IAP) gene products play an evolutionarily conserved role in regulating programmed cell death in diverse… Expand
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