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BIRC2 gene

Known as: HIAP2, c-IAP1, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2 
This gene is a potent inhibitor of apoptosis and plays an important role in apoptotic signal transduction.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Three members of the IAP family (X-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis proteins-1/-2 (cIAP1 and… Expand
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Highly Cited
2009
Highly Cited
2009
Cellular inhibitor of apoptosis proteins (cIAPs) block apoptosis, but their physiological functions are still under investigation… Expand
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Highly Cited
2008
Highly Cited
2008
Recent studies suggest that nuclear factor κB-inducing kinase (NIK) is suppressed through constitutive proteasome-mediated… Expand
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Highly Cited
2007
Highly Cited
2007
Summary XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be relieved by IAP antagonists… Expand
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Highly Cited
2007
Highly Cited
2007
XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be relieved by IAP antagonists, such as… Expand
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Highly Cited
2006
Highly Cited
2006
The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through… Expand
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Highly Cited
2002
Highly Cited
2002
Inhibitor of apoptosis (IAP) proteins inhibit caspases, a function counteracted by IAP antagonists, insect Grim, HID, and Reaper… Expand
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Highly Cited
2000
Highly Cited
2000
To identify proteins that bind mammalian IAP homolog A (MIHA, also known as XIAP), we used coimmuno-precipitation and 2D… Expand
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Highly Cited
2000
Highly Cited
2000
To determine why proteasome inhibitors prevent thymocyte death, we examined whether proteasomes degrade anti-apoptotic molecules… Expand
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Highly Cited
1996
Highly Cited
1996
Baculovirus inhibitors of apoptosis (IAPs) act in insect cells to prevent cell death. Here we describe three mammalian homologs… Expand
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