BIRC2 gene

Known as: HIAP2, c-IAP1, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2 
This gene is a potent inhibitor of apoptosis and plays an important role in apoptotic signal transduction.
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Three members of the IAP family (X-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis proteins-1/-2 (cIAP1 and… (More)
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Highly Cited
2011
Highly Cited
2011
The inhibitor of apoptosis (IAP) proteins are important ubiquitin E3 ligases that regulate cell survival and oncogenesis. The… (More)
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Highly Cited
2007
Highly Cited
2007
XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be relieved by IAP antagonists, such as… (More)
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Highly Cited
2007
Highly Cited
2007
James E. Vince,1 W. Wei-Lynn Wong,1,8 Nufail Khan,1,8 Rebecca Feltham,1,8 Diep Chau,1 Afsar U. Ahmed,1 Christopher A. Benetatos,2… (More)
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Highly Cited
2006
Highly Cited
2006
The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibitor of apoptosis (IAP) proteins inhibit caspases, a function counteracted by IAP antagonists, insect Grim, HID, and Reaper… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibitor of apoptosis proteins (IAPs) interact with and inhibit caspases-3, -7, and -9. This interaction can be inhibited by… (More)
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Highly Cited
2000
Highly Cited
2000
To identify proteins that bind mammalian IAP homolog A (MIHA, also known as XIAP), we used coimmuno-precipitation and 2D… (More)
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Highly Cited
2000
Highly Cited
2000
To determine why proteasome inhibitors prevent thymocyte death, we examined whether proteasomes degrade anti-apoptotic molecules… (More)
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Review
2000
Review
2000
ABSTRACTIAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins… (More)
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