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BIRC2 gene

Known as: HIAP2, c-IAP1, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2 
This gene is a potent inhibitor of apoptosis and plays an important role in apoptotic signal transduction.
National Institutes of Health

Related topics

Related topics

4 relations
ApoptosisBIRC2 protein, humanBIRC2 wt AlleleNegative Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate
Antiretroviral therapy (ART) suppresses HIV replication, but does not cure the infection because replication-competent virus… 
Review
2013
Review
2013
Emerging role of the ubiquitin-proteasome system as drug targets.
The ubiquitin-proteosome system (UPS) regulates a wide range of cellular processes including protein degradation, DNA repair… 
2011
2011
Cucurbitacin B suppresses the transactivation activity of RelA/p65
Cucurbitacin B, a natural triterpenoid is well‐known for its strong anticancer activity, and recent studies showed that the… 
2010
2010
Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and…
Cellular inhibitor of apoptosis (cIAP) proteins, cIAP1 and cIAP2, are important regulators of tumor necrosis factor (TNF… 
2010
2010
Abstract 2775: A phase I study of LCL161, an oral IAP inhibitor, in patients with advanced cancer
Introduction: LCL161 is a potent small molecule mimetic of the Smac mitochondrial protein. Like Smac, it binds to inhibitor of… 
2007
2007
Inhibition of caspase‐dependent spontaneous apoptosis via a cAMP‐protein kinase A dependent pathway in neutrophils from sickle cell disease patients
Sickle cell disease (SCD) is a chronic inflammatory condition characterized by high leucocyte counts, altered cytokine levels and… 
2005
2005
IAPs – the ubiquitin connection
One way or another, almost all proteins containing baculoviralIAP repeat domains (BIRs) have been associated withubiquitin (the… 
Highly Cited
2000
Highly Cited
2000
Heterogeneity of the API2-MALT1 gene rearrangement in MALT-type lymphoma
The translocation t(11;18)(q21;q21), which is the most frequent chromosomal aberration in extranodal marginal zone B cell… 
2000
2000
Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2.
Tumor necrosis factor (TNF) receptor (TNFR)-associated factors 1 and 2 (TRAF1 and TRAF2) and inhibitor of apoptosis proteins… 
1997
1997
Genomic organization and primary characterization of miap-3: the murine homologue of human X-linked IAP.
IAPs (inhibitor of apoptosis proteins) are a recently identified family of proteins that function in the cell death pathway to… 
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