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Arachidonate 15-Lipoxygenase

Known as: 15-Lipoxygenase, Arachidonate, EC 1.13.11.33, 15-Lipoxygenase, Reticulocyte Arachidonate 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5… Expand
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Chronic inflammation plays a major role in atherogenesis and understanding the role of inflammation and its resolution will offer… Expand
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Highly Cited
2005
Highly Cited
2005
Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we… Expand
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Highly Cited
2004
Highly Cited
2004
In mammals, lipoxygenases play key roles in inflammation by initiating the transformation of arachidonic acid into potent… Expand
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Highly Cited
2003
Highly Cited
2003
PGs and leukotrienes (LTs) mediate cardinal signs of inflammation; hence, their enzymes are targets of current anti-inflammatory… Expand
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Highly Cited
2003
Highly Cited
2003
Oxidation products of low-density lipoproteins have been suggested to promote inflammation during atherogenesis, and reticulocyte… Expand
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Highly Cited
2001
Highly Cited
2001
BackgroundThe enzyme 12/15-lipoxygenase (12/15-LO) has been implicated in the oxidative modification of LDL. In a murine model… Expand
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Review
2000
Review
2000
The demonstration of in vivo arachidonic acid epoxidation and omega-hydroxylation established the cytochrome P450 epoxygenase and… Expand
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Highly Cited
1998
Highly Cited
1998
Diets high in fat are associated with an increased risk of prostate cancer, although the molecular mechanism is still unknown. We… Expand
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Highly Cited
1998
Highly Cited
1998
Oxidative modification of low density lipoprotein (LDL) has been implicated in atherogenesis. Evidence consistent with this… Expand
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Highly Cited
1997
Highly Cited
1997
Here we report the first structure of a mammalian 15-lipoxygenase. The protein is composed of two domains; a catalytic domain and… Expand
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