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Arachidonate 15-Lipoxygenase

Known as: 15-Lipoxygenase, Arachidonate, EC 1.13.11.33, 15-Lipoxygenase, Reticulocyte Arachidonate 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5… 
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (2)

12-15-lipoxygenaseALOX15B protein, human
ALOX15 geneAnabolismCytoplasmEnzyme Gene

Papers overview

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Highly Cited
2004
Highly Cited
2004
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.
Highly Cited
2003
Highly Cited
2003
Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators 1
PGs and leukotrienes (LTs) mediate cardinal signs of inflammation; hence, their enzymes are targets of current anti-inflammatory… 
Review
2000
Review
2000
Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase.
The demonstration of in vivo arachidonic acid epoxidation and omega-hydroxylation established the cytochrome P450 epoxygenase and… 
Highly Cited
1999
Highly Cited
1999
Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants.
Highly Cited
1998
Highly Cited
1998
Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice
Oxidative modification of low density lipoprotein (LDL) has been implicated in atherogenesis. Evidence consistent with this… 
Highly Cited
1992
Highly Cited
1992
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.
Arachidonate 15-lipoxygenase (arachidonate:oxygen 15-oxidoreductase, EC 1.13.11.33) is a lipid-peroxidating enzyme that is… 
Highly Cited
1992
Highly Cited
1992
The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein.
Oxidation of low density lipoprotein (LDL) has been shown to occur in the artery wall of atherosclerotic lesions in both animal… 
Highly Cited
1991
Highly Cited
1991
5-lipoxygenase inhibitory activity of zileuton.
Zileuton [N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyure] inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic… 
Highly Cited
1989
Highly Cited
1989
Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus
LONG-term potentiation (LTP) is a widely studied model of the synaptic basis of information storage in the mammalian brain1, 2… 
Highly Cited
1984
Highly Cited
1984
Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.
Trihydroxytetraenes, a novel series of oxygenated derivatives formed from arachidonic acid in human leukocytes, were recently… 
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