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Arachidonate 15-Lipoxygenase

Known as: 15-Lipoxygenase, Arachidonate, EC 1.13.11.33, 15-Lipoxygenase, Reticulocyte Arachidonate 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5… 
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (2)

12-15-lipoxygenaseALOX15B protein, human
ALOX15 geneAnabolismCytoplasmEnzyme Gene

Papers overview

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Review
2000
Review
2000
Lipoxygenases and atherosclerosis: protection versus pathogenesis.
Review
1999
Review
1999
15-Lipoxygenase and its inhibition: a novel therapeutic target for vascular disease.
The disease process known as atherosclerosis is the leading cause of morbidity and mortality in the Western world. Current… 
Highly Cited
1998
Highly Cited
1998
Expression of 15-Lipoxygenase by Human Colorectal Carcinoma Caco-2 Cells during Apoptosis and Cell Differentiation*
We studied arachidonic acid metabolism and the expression of cyclooxygenase (Cox) and 15-lipoxygenase (15-LO) in the human… 
Highly Cited
1993
Highly Cited
1993
Molecular cloning of a 12-lipoxygenase cDNA from rat brain.
A cDNA encoding an arachidonate 12-lipoxygenase from rat brain was obtained by polymerase chain reaction cloning. Primers… 
Highly Cited
1993
Highly Cited
1993
Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases.
When arachidonate 12-lipoxygenase purified from porcine leukocytes was incubated aerobically with 1-palmitoyl-2-arachidonoyl-sn… 
Highly Cited
1990
Highly Cited
1990
Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells.
Highly Cited
1985
Highly Cited
1985
Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4.
Highly Cited
1983
Highly Cited
1983
Stereospecific inhibition of PGH2-induced platelet aggregation by lipoxygenase products of icosaenoic acids.
Highly Cited
1982
Highly Cited
1982
Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids.
Highly Cited
1981
Highly Cited
1981
Arachidonic acid 15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Partial purification and properties.
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