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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
Pyridine derivative Y-27632 consistently suppresses Rho-induced, p160ROCK-mediated formation of stress fibres in cultured cells and dramatically corrects hypertension in several hypertensive rat models, suggesting that compounds that inhibit this process might be useful therapeutically. Expand
Prostanoid receptors: structures, properties, and functions.
An overview of the current status of research on the prostanoid receptors is given and domains and amino acid residues conferring the specificities of ligand binding and signal transduction are being clarified. Expand
International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.
Y-27632 and Y-30141 inhibited the kinase activity of both ROCK-I and ROCK-II in vitro, and this inhibition was reversed by ATP in a competitive manner, suggesting that these compounds inhibit the kinases by binding to the catalytic site. Expand
Prostaglandin E Receptors*
Recent advances in PGE receptor research are reviewed, including studies on knock-out mice deficient in each EP subtype have defined PGE2 actions mediated by each subtype and identified the role eachEP subtype plays in various physiological and pathophysiological responses. Expand
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Results indicate that phosphorylation of LIM-kinase by ROCK and consequently increased phosphorylated of cofilin by LIM- Kinase contribute to Rho-induced reorganization of the actin cytoskeleton. Expand
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
- N. Watanabe, Takayuki Kato, A. Fujita, T. Ishizaki, S. Narumiya
- Biology, Medicine
- Nature Cell Biology
- 1 July 1999
It is shown that GTP-bound Rho activates its effector mDia1 by disrupting mDIA1’s intramolecular interactions, which may induce the formation of different actin structures affected by the balance between mDía1 and ROCK signalling. Expand
Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism
Experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force, and that external tension force bypasses the requirement for ROCK-mediated myosin II contractility in the induction of focal contacts. Expand
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
Southern blot analyses and genomic cloning demonstrates the existence of related genes, raising the possibility that similar abnormalities in related genes may give rise to diseases similar to Machado-Joseph disease. Expand
p140mDia, a mammalian homolog of Drosophila diaphanous,is a target protein for Rho small GTPase and is a ligand for profilin
Results suggest that Rho regulates actin polymerization by targeting profilin via p140mDia beneath the specific plasma membranes. Expand