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Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: contributions to atherosclerosis.
  • M. Cathcart
  • Chemistry, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 2004
The current understanding of the signal transduction pathways regulating NADPH oxidase activation and related superoxide anion production in activated human monocytes is summarized and novel pathways are identified that may serve as future targets for therapeutic intervention in this pathogenic process. Expand
IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages.
It is demonstrated here that IL-13 and IL-4 can uniquely affect the expression of particular genes such as dual-specificity phosphatase 1 and tissue inhibitor of metalloprotease-3 and do so through different Jaks and add novel insights into the pathogenesis and potential treatment of various inflammatory diseases. Expand
Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic
This is the first demonstration that short‐lived free radicals emanating from phagocytic cells could mediate cell injury through the action of a stable cytotoxin formed by the oxidation of LDL. Expand
The Oxidation of Lipoproteins by Monocytes-Macrophages
It is taken that monocyte-derived macrophages are likely candidates to mediate the in vivo oxidation of lipoproteins, because they are prominent in arterial lesions, known to generate activation-dependent reactive oxygen species, and, unlike EC and SMC, capable in vitro of LDL oxidation in media free of metal ion additives. Expand
CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis.
Findings suggest that monocytes competent to enter the CNS compartment derive from a minority CCR1+/CCR5+ population in the circulating pool, and that in the presence of ligand, these cells will be retained in the CNS. Expand
Protein Kinase Cδ Is Required for p47phox Phosphorylation and Translocation in Activated Human Monocytes1
It is suggested that PKCδ plays a pivotal role in stimulating monocyte NADPH oxidase activity through its regulation of the phosphorylation and translocation of p47phox. Expand
Silencing IL-13Rα2 Promotes Glioblastoma Cell Death via Endogenous Signaling
Findings identify a mechanism for eliminating the blockade of endogenous IL-13 signaling and for promotion of apoptosis, and characterize a role for 15-LOX-1 in GBM apoptosis. Expand
Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques.
It is concluded that 15-lipoxygenase contributes to the formation of oxidized lipids in human atherosclerotic lesions. Expand
Selective Inhibition of Cytosolic Phospholipase A2 in Activated Human Monocytes
  • Qing Li, M. Cathcart
  • Medicine, Chemistry
  • The Journal of Biological Chemistry
  • 24 January 1997
These studies support the proposal that cPLA2 activity is required for activated monocytes to oxidize LDL lipids. Expand
Signal Transducer and Activator of Transcription 1 Is Required for Optimal Foam Cell Formation and Atherosclerotic Lesion Development
The regulation of CD36 expression by Stat1 may be important in other pathophysiological CD36-dependent events; the Stat1 regulation of foam cell formation requires CD36. Expand