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Apolipoprotein E3

Known as: APOE epsilon 3, Isoapolipoprotein E3, APOE epsilon3 
A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human… 
National Institutes of Health

Related topics

Related topics

11 relations
Apolipoprotein E3:PrThr:Pt:Bld:OrdIn BloodProcess of secretionagonists

Narrower (2)

apolipoprotein E3 (Kochi)apolipoprotein E7, human

Papers overview

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Highly Cited
2004
Highly Cited
2004
Apolipoprotein E Receptors Mediate Neurite Outgrowth through Activation of p44/42 Mitogen-activated Protein Kinase in Primary Neurons*
Several ligands of the endocytic low density lipoprotein receptor-related protein (LRP), such as apoE-containing lipoproteins and… 
Highly Cited
2002
Highly Cited
2002
Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis
The association of the E4 allele of apolipoprotein E (apoE4) as a genetic risk factor for Alzheimer's disease (AD) has been well… 
Highly Cited
2001
Highly Cited
2001
Human apolipoprotein E4 accelerates β‐amyloid deposition in APPsw transgenic mouse brain
The human apolipoprotein E4 (ApoE4) isoform is associated with genetic risk for Alzheimer's disease. To assess the effects of… 
Review
2000
Review
2000
Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid‐β deposition in vivo
The genetic association between the E4 isoform of apolipoprotein E (apoE) and increased risk for Alzheimer's disease (AD) has… 
Highly Cited
1998
Highly Cited
1998
Differential Cellular Accumulation/Retention of Apolipoprotein E Mediated by Cell Surface Heparan Sulfate Proteoglycans
Isoform-specific effects of apolipoprotein E (apoE) on neurite outgrowth and the cytoskeleton are associated with higher… 
Highly Cited
1997
Highly Cited
1997
Characterization of the Binding of Amyloid‐β Peptide to Cell Culture‐Derived Native Apolipoprotein E2, E3, and E4 Isoforms and to Isoforms from Human Plasma
Abstract: The ε4 allele of apolipoprotein E (apoE, protein; APOE, gene) is a major risk factor for Alzheimer's disease (AD… 
Highly Cited
1996
Highly Cited
1996
Differential Binding of Apolipoprotein E Isoforms to Tau and Other Cytoskeletal Proteins
The apolipoprotein E4 (apoE4) gene dose is a major risk factor for late-onset and sporadic Alzheimer's disease with 50% of… 
Highly Cited
1995
Highly Cited
1995
Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans.
Highly Cited
1994
Highly Cited
1994
Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease
Highly Cited
1983
Highly Cited
1983
Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype.
A type III hyperlipoproteinemic subject having the apolipoprotein E (apo E) phenotype E3/2 was identified. From isoelectric… 
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