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Apolipoprotein E3

Known as: APOE epsilon 3, Isoapolipoprotein E3, APOE epsilon3 
A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human… 
National Institutes of Health

Related topics

Related topics

11 relations
Apolipoprotein E3:PrThr:Pt:Bld:OrdIn BloodProcess of secretionagonists

Narrower (2)

apolipoprotein E3 (Kochi)apolipoprotein E7, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Exercise improves cognition and hippocampal plasticity in APOE ε4 mice
Highly Cited
2005
Highly Cited
2005
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor Published, JLR Papers in Press, May 1, 2005. DOI 10.1194/jlr.M500114-JLR200
Apolipoprotein E (apoE) associates with lipoproteins and mediates their interaction with members of the LDL receptor family. ApoE… 
Highly Cited
2001
Highly Cited
2001
Behavioral Phenotyping of GFAP-ApoE3 and -ApoE4 Transgenic Mice: ApoE4 Mice Show Profound Working Memory Impairments in the Absence of Alzheimer's-like Neuropathology
For the purpose of studying the potential neurobehavioral effects of different human apolipoprotein E (apoE) isoforms produced… 
Review
2000
Review
2000
Lipoproteins in the Central Nervous System
Abstract: Although the synthesis and metabolism of plasma lipoproteins are well characterized, little is known about lipid… 
Highly Cited
1995
Highly Cited
1995
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.
The epsilon 4 allele of apolipoprotein E (apoE) is a major risk factor for Alzheimer disease, suggesting that apoE may directly… 
Highly Cited
1995
Highly Cited
1995
The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization (*)
Evidence is presented for the differential effects of two isoforms of apolipoprotein (apo) E, apoE3 and apoE4, on neurite… 
Highly Cited
1995
Highly Cited
1995
Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth (*)
Previously, we demonstrated in cultured dorsal root ganglion neurons that, in the presence of β-migrating very low density… 
Highly Cited
1995
Highly Cited
1995
Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease.
The apolipoprotein E4 (APOE4) allele is associated with an early age of onset of the nonfamilial form of Alzheimer disease (AD… 
Highly Cited
1990
Highly Cited
1990
Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.
Human apolipoprotein (apo) E occurs as three common isoforms (apoE4, E3, and E2), all of which influence plasma cholesterol… 
Highly Cited
1986
Highly Cited
1986
Abnormal in vivo metabolism of apolipoprotein E4 in humans.
Apolipoprotein E (apoE) is important in modulating the catabolism of remnants of triglyceride-rich lipoprotein particles. It is a… 
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