Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
- R. Mahley
- 29 April 1988
Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and…
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
It is demonstrated that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.
Apolipoprotein E: far more than a lipid transport protein.
Functional differences in the apoE isoforms that affect (or did affect) survival before the reproductive years probably account, at least in part, for the allele frequencies of the present day.
Ancient human genomes suggest three ancestral populations for present-day Europeans
It is shown that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians; and early European farmers, who were mainly of Near Eastern origin but also harboured west Europeanhunter-gatherer related ancestry.
Plasma lipoproteins: apolipoprotein structure and function.
- R. Mahley, T. Innerarity, S. C. Rall, K. Weisgraber
- Biology, ChemistryJournal of Lipid Research
- 1 December 1984
Future studies will rely heavily on the use of recombinant DNA technology and site-specific mutagenesis to elucidate further the correlations between structure and function and the role of specific apolipoproteins in lipoprotein metabolism.
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.
- R. Mahley, K. Weisgraber, Yadong Huang
- BiologyProceedings of the National Academy of Sciences…
- 11 April 2006
The premise of this review is that apolipoprotein (apo) E4 is much more than a contributing factor to neurodegeneration, and potential therapeutic strategies are suggested, including the use of "structure correctors" to convert apoE4 to an "apoE3-like" molecule, protease inhibitors to prevent the generation of toxic apOE4 fragments, and "mitochondrial protector" to prevent cellular energy disruption.
Turkish Heart Study: lipids, lipoproteins, and apolipoproteins.
The Turkish people were found to have very low levels of high density lipoprotein (HDL) cholesterol (HDE) and total cholesterol/HDL-C ratios that were high and smoking, a major risk factor for heart disease, was very prevalent in the Turkish population.
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E.
Cell-surface HSPG play a critical role in remnant uptake, not only in the important initial sequestration or capture step in the space of Disse, but also as an essential or integral component of the H SPG-LRP pathway.
Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.
- T. Innerarity, K. Weisgraber, S. Grundy
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 October 1987
These studies indicate that the defective receptor binding results in inefficient clearance of LDL and the hypercholesterolemia observed in patients, which has been designated familial defective apolipoprotein B-100.