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Androgen-Insensitivity Syndrome

Known as: DHTR DEFICIENCY, Insensitivity Syndrome, Androgen, Resistance Syndrome, Androgen 
A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to… 
National Institutes of Health

Related topics

Related topics

27 relations
AR geneAR wt AlleleAchard-Thiers syndromeAndrogen Receptor Deficiency

Broader (5)

Adrenogenital SyndromeDisorders of Sex DevelopmentGenital Diseases, MaleSex Chromosome Aberrations

Narrower (3)

Reifenstein SyndromeTesticular FeminizationType I familial incomplete male pseudohermaphroditism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Neuronal nitric oxide synthase and calbindin delineate sex differences in the developing hypothalamus and preoptic area
Throughout the hypothalamus there are several regions known to contain sex differences in specific cellular, neurochemical, or… 
Highly Cited
2001
Highly Cited
2001
Effect of atenolol on cadmium-induced testicular toxicity in male rats.
Highly Cited
1999
Highly Cited
1999
Estrogen in autoimmunity: expression of estrogen receptors in thymic and autoimmune T cells.
OBJECTIVE To identify the targets of estrogen in immune system lymphocytes and to examine gender differences in autoimmunity… 
Review
1997
Review
1997
Phenotypic diversity in siblings with partial androgen insensitivity syndrome
The androgen insensitivity syndrome is a heterogeneous disorder with a wide spectrum of phenotypic abnormalities, ranging from… 
Highly Cited
1990
Highly Cited
1990
Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity.
Mutations in the androgen receptor (AR) are thought to cause complete androgen insensitivity (CAIS) in 46,XY human subjects who… 
Highly Cited
1984
Highly Cited
1984
Sex steroid modulation of the serotonin behavioral syndrome.
Highly Cited
1982
Highly Cited
1982
Human complete androgen insensitivity with normal dihydrotestosterone receptor binding capacity in cultured genital skin fibroblasts: evidence for a qualitative abnormality of the receptor.
Complete androgen insensitivity syndrome (CAIS), or so-called testicular feminization, results from the lack of androgen action… 
Highly Cited
1979
Highly Cited
1979
Down-regulation of testicular androgen biosynthesis and LH receptor levels by an LHRH agonist: role of prolactin
Highly Cited
1972
Highly Cited
1972
Androgen and gonadotropin dynamics in testicular feminization syndrome.
Four adult siblings with the complete form of testicular feminization (TFS) were studied before and after gonadectomy. The mean… 
Highly Cited
1969
Highly Cited
1969
An explanation for the target organ unresponsiveness to testosterone in the testicular feminization syndrome.
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