• Publications
  • Influence
Clinical trials in head injury.
Traumatic brain injury (TBI) remains a major public health problem globally. In the United States the incidence of closed head injuries admitted to hospitals is conservatively estimated to be 200 perExpand
  • 282
  • 17
Serial microPET measures of the metabolic reaction to a microdialysis probe implant
Despite the widespread use of chronic brain implants in experimental and clinical settings, the effects of these long-term procedures on brain metabolism and receptor expression remain largelyExpand
  • 128
  • 15
Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficits.
Traumatic brain injury is a leading cause of mortality and morbidity among young people. For the last couple of decades, it was believed that excess stimulation of brain receptors for the excitatoryExpand
  • 209
  • 12
  • PDF
Distribution of Glutamate Transporter Subtypes During Human Brain Development
Abstract: In the mature brain, removal of glutamate from the synaptic cleft plays an important role in the maintenance of subtoxic levels of glutamate. This requirement is handled by a family ofExpand
  • 136
  • 9
Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation
Although impaired inhibitory control is linked to a broad spectrum of health problems, including obesity, the brain mechanism(s) underlying voluntary control of hunger are not well understood. WeExpand
  • 187
  • 8
  • PDF
Regionally selective increases in μ opioid receptor density in the brains of suicide victims
The effect of ageing and suicide on mu opioid receptors was studied in the human brain postmortem. Quantitative autoradiography with [3H]DAGO revealed region specific increases in mu receptor densityExpand
  • 152
  • 7
Human corpus callosum in aging and alzheimer's disease: a magnetic resonance imaging study
The involvement of the corpus callosum in aging and Alzheimer's disease (AD) is not clear. We measured cross sectional areas of the entire corpus callosum (CC), as well as the front 20% (genu),Expand
  • 96
  • 6
Gene x disease interaction on orbitofrontal gray matter in cocaine addiction.
CONTEXT Long-term cocaine use has been associated with structural deficits in brain regions having dopamine-receptive neurons. However, the concomitant use of other drugs and common geneticExpand
  • 74
  • 5
  • PDF
Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in mice.
Traumatic brain injury (TBI) triggers a massive glutamate efflux, hyperactivation of N-methyl-D-aspartate receptors (NMDARs) and neuronal cell death. Previously it was demonstrated that, 15 minExpand
  • 60
  • 5
Neural mechanisms of anger regulation as a function of genetic risk for violence.
Genetic risk may predispose individuals to compromised anger regulation, potentially through modulation of brain responses to emotionally evocative stimuli. Emphatically expressed, the emotional wordExpand
  • 62
  • 5
  • PDF