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Affinity

The strength of noncovalent chemical binding between two substances as measured by the dissociation constant of the complex.(On-line Medical… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small… Expand
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Highly Cited
2003
Highly Cited
2003
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic… Expand
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Highly Cited
1998
Highly Cited
1998
DNA sequences that position nucleosomes are of increasing interest because of their relationship to gene regulation in vivo and… Expand
Highly Cited
1993
Highly Cited
1993
Examination of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association… Expand
Highly Cited
1992
Highly Cited
1992
GLUTAMATE transport across plasma membranes of neurons, glial cells and epithelial cells of the small intestine and kidney… Expand
Highly Cited
1991
Highly Cited
1991
Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking… Expand
Highly Cited
1991
Highly Cited
1991
The role of low affinity, heparin-like binding sites for basic fibroblast growth factor (bFGF) was investigated in CHO cells… Expand
Highly Cited
1990
Highly Cited
1990
High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on alternate cycles of ligand… Expand
Highly Cited
1989
Highly Cited
1989
The high affinity of the noncovalent interaction between biotin and streptavidin forms the basis for many diagnostic assays that… Expand
Highly Cited
1980
Highly Cited
1980
We have developed a general strategy and a versatile computer program for analysis of data from ligand-binding experiments (e.g… Expand