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The strength of noncovalent chemical binding between two substances as measured by the dissociation constant of the complex.(On-line Medical… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Recent years have witnessed rapid developments of computer-aided drug design methods, which have reached accuracy that allows… Expand
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Review
2018
Review
2018
Contractile tail bacteriophages, or myobacteriophages, use a sophisticated biomolecular structure to inject their genome into the… Expand
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Review
2017
Review
2017
Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells expressing six Prx isoforms (PrxI to PrxVI… Expand
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Review
2017
Review
2017
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation… Expand
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Review
2017
Review
2017
Safety and efficacy constitute the major criteria governing regulatory approval of any new drug. The best method to maximize… Expand
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Review
2017
Review
2017
Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellular matrix. In this Review, we… Expand
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Highly Cited
2009
Highly Cited
2009
Distinct genes encode 6 human receptors for IgG (hFcgammaRs), 3 of which have 2 or 3 polymorphic variants. The specificity and… Expand
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Highly Cited
2008
Highly Cited
2008
Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small… Expand
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Highly Cited
2003
Highly Cited
2003
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic… Expand
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Highly Cited
1995
Highly Cited
1995
Thiazolidinedione derivatives are antidiabetic agents that increase the insulin sensitivity of target tissues in animal models of… Expand
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