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Affinity

The strength of noncovalent chemical binding between two substances as measured by the dissociation constant of the complex.(On-line Medical… 
National Institutes of Health

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Highly Cited
1998
Highly Cited
1998
Regenerable biosensor platform: a total internal reflection fluorescence cell with electrochemical control.
A new biosensor platform that provides simultaneous fluorescence detection and electrochemical control of biospecific binding has… 
Highly Cited
1986
Highly Cited
1986
High-affinity binding sites for human Glu-plasminogen unveiled by limited plasmic degradation of human fibrin.
The binding of human 125I-Glu-plasminogen to human plasmin-degraded fibrin was studied. Treatment of preformed and polymerized… 
Highly Cited
1984
Highly Cited
1984
A chemoattractant receptor on macrophages exists in two affinity states regulated by guanine nucleotides
The binding characteristics of the oligopeptide chemoattractant receptor on guinea pig macrophages and macrophage membrane… 
Highly Cited
1984
Highly Cited
1984
Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid.
We have examined the calcium-binding properties and metal ion-dependent conformational changes of proteolytically modified… 
Highly Cited
1980
Highly Cited
1980
Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea.
Three immunological methods [radioimmunoassay (RIA), enzyme-linked immunosorbent assay, and radioimmunosorbent technique] were… 
Highly Cited
1979
Highly Cited
1979
Correlation between metabolic reduction rates and electron affinity of nitroheterocycles.
Nitroheterocyclic compounds can selectively sensitize hypoxic (tumor) cells to radiation damage in vitro. However, results in… 
Highly Cited
1978
Highly Cited
1978
Membrane enzymes: artifacts in Arrhenius plots due to temperature dependence of substrate-binding affinity.
For the membrane sodium-stimulated magnesium-adenosinetriphosphatase of Acholeplasma laidlawii B both the Vmax and Km values in… 
Highly Cited
1977
Highly Cited
1977
Purification of glycolytic enzymes by using affinity-elution chromatography.
1. A systematic procedure for the purification of enzymes by affinity-elution chromatography is described. Enzymes are adsorbed… 
Highly Cited
1974
Highly Cited
1974
The effects of protein malnutrition on macrophage function and the amount and affinity of antibody response.
Ajax mice fed a diet with a reduced proportion of protein, cleared carbon more slowly, and produced less antibody of lower… 
Highly Cited
1970
Highly Cited
1970
Specific separation of cells on affinity columns.
Cell filtration is performed on affinity columns prepared by the chemical modification of large polyacrylamide beads. Affinity…