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Phosphoinositides: tiny lipids with giant impact on cell regulation.
  • T. Balla
  • Biology, Medicine
    Physiological reviews
  • 1 July 2013
This review is an attempt to give an overview of this enormous research field focusing on major developments in diverse areas of basic science linked to cellular physiology and disease.
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels
It is demonstrated that VDAC1 is physically linked to the endoplasmic reticulum Ca2+-release channel inositol 1,4,5-trisphosphate receptor (IP3R) through the molecular chaperone glucose-regulated protein 75 (grp75) and functional interaction between the channels was shown by the recombinant expression of the ligand-binding domain of the IP3R on the ER or mitochondrial surface.
Structural and functional features and significance of the physical linkage between ER and mitochondria
An unexpected dependence of cell function and survival is revealed on the maintenance of proper spacing between the ER and mitochondria, which makes mitochondria prone to Ca2+ overloading and ensuing permeability transition.
Visualization of Phosphoinositides That Bind Pleckstrin Homology Domains: Calcium- and Agonist-induced Dynamic Changes and Relationship to Myo-[3H]inositol-labeled Phosphoinositide Pools
Identification and dynamic imaging of phosphoinositides that interact with PH domains will further the understanding of the regulation of such proteins by inositol phospholipids.
Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication
It is shown how RNA viruses can manipulate multiple components of the cellular secretory pathway to generate organelles specialized for replication that are distinct in protein and lipid composition from the host cell.
Phosphatidylinositol 4-kinases: old enzymes with emerging functions.
The four mammalian PtdIns 4-kinases regulate a diverse array of signaling events, as well as vesicular trafficking and lipid transport, but the mechanisms by which their lipid product Ptdins 4-phosphate controls these processes is only beginning to unfold.
Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic
Results demonstrate that PIP 5-kinase activity and PIP2 turnover controlled by activation and inactivation of Arf6 is critical for trafficking through the Arf 6 PM-endosomal recycling pathway.
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.
Morphologic polarity is necessary for chemotaxis of mammalian cells and the pleckstrin homology domain of the AKT protein kinase, tagged with the green fluorescent protein (PHAKT-GFP), was expressed in neutrophils to probe intracellular signals responsible for this asymmetry.