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Phosphoinositides: tiny lipids with giant impact on cell regulation.
  • T. Balla
  • Biology, Medicine
  • Physiological reviews
  • 1 July 2013
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they control almost all aspects of a cell's life and death. These lipids gained tremendous research interest asExpand
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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels
The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane mediates metabolic flow, Ca2+, and cell death signaling between the endoplasmic reticulum (ER) and mitochondrialExpand
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Structural and functional features and significance of the physical linkage between ER and mitochondria
The role of mitochondria in cell metabolism and survival is controlled by calcium signals that are commonly transmitted at the close associations between mitochondria and endoplasmic reticulum (ER).Expand
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Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication
Summary Many RNA viruses remodel intracellular membranes to generate specialized sites for RNA replication. How membranes are remodeled and whatExpand
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A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologicallyExpand
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Visualization of Phosphoinositides That Bind Pleckstrin Homology Domains: Calcium- and Agonist-induced Dynamic Changes and Relationship to Myo-[3H]inositol-labeled Phosphoinositide Pools
Phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P2) pools that bind pleckstrin homology (PH) domains were visualized by cellular expression of a phospholipase C (PLC)δ PH domain–green fluorescentExpand
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Phosphatidylinositol 4-kinases: old enzymes with emerging functions.
Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely important in the regulation of the recruitment and activity of many signaling proteins in cellularExpand
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Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic
ADP-ribosylation factor (Arf) 6 regulates the movement of membrane between the plasma membrane (PM) and a nonclathrin-derived endosomal compartment and activates phosphatidylinositol 4-phosphateExpand
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Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.
Morphologic polarity is necessary for chemotaxis of mammalian cells. As a probe of intracellular signals responsible for this asymmetry, the pleckstrin homology domain of the AKT protein kinase (orExpand
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A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
Characterization of a new biosensor for PtdIns4P reveals a wider cellular distribution for the polyphosphoinositide than the Golgi localization reported previously, including pools in both the plasmaExpand
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