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International union of pharmacology. XXIII. The angiotensin II receptors.
TLDR
Although AT(1) receptors mediate most of the known actions of Ang II, the AT(2) receptor contributes to the regulation of blood pressure and renal function and the development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system.
Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II.
TLDR
The recognition of Ang II's pathogenic actions is leading to novel clinical applications of angiotensin-converting enzyme inhibitors and AT1R antagonists, in addition to their established therapeutic actions in essential hypertension.
A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids.
TLDR
The results indicate that a specific WT-sensitive PtdIns 4-kinase is critical for the maintenance of the agonist-sensitive polyphosphoinositide pool in several cell types.
Gonadotropin-releasing hormone receptors: structure and signal transduction pathways.
TLDR
The review addressed the interactions between cytoplasmic calcium and protein kinase C (PKC) in the control of gonadotropin synthesis and release, as well as the participation of phospholipase D (PLD), arachidonic acid (AA) and its metabolites in GnRHinduced signaling.
Angiotensin receptors and their antagonists.
TLDR
The intrarenal renin–angiotensin system affects glomerular filtration, as discussed below, but the importance of ang Elliotensin synthesis in other tissues is not known.
Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor
TLDR
Data indicate that internalized AT1 receptors are processed via vesicles that resemble multivesicular bodies, and recycle to the cell surface by a rapid PI 3-kinase–dependent recycling route, as well as by a slower pathway that is less sensitive to PI 3,kinase inhibitors.
Cloning and Expression of cDNA Encoding a Rat Adrenomedullin Receptor (*)
TLDR
The identification of a cDNA clone for the adrenomedullin receptor that was originally isolated as an orphan receptor from rat lung is reported, which encodes a polypeptide of 395 residues that contains seven transmembrane domains and has a general structural resemblance to other members of the G protein-linked receptor superfamily.
Effects of Second Intracellular Loop Mutations on Signal Transduction and Internalization of the Gonadotropin-releasing Hormone Receptor (*)
TLDR
It is demonstrated that substitution of Ser by Tyr does not affect G protein coupling but significantly increases receptor affinity and internalization rate, and replacement of a conserved aliphatic residue (Leu) impairs both Gprotein coupling and agonist-induced receptor internalization.
Roles of Src and Epidermal Growth Factor Receptor Transactivation in Transient and Sustained ERK1/2 Responses to Gonadotropin-releasing Hormone Receptor Activation*
TLDR
The results indicate that the duration of ERK1/2 activation depends on the signaling pathways utilized by GnRH in specific target cells and suggest that transactivation of the tightly regulated EGFR can account for the transient ERK 1/2 responses that are elicited by stimulation of certain G protein-coupled receptors.
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