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International union of pharmacology. XXIII. The angiotensin II receptors.
The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT(1) and AT(2) receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. Most speciesExpand
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Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II.
Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1 receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium balance and itsExpand
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A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids.
The synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], the immediate precursor of intracellular signals generated by calcium-mobilizing hormones and growth factors, is initiated byExpand
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Gonadotropin-releasing hormone receptors: structure and signal transduction pathways.
SEVERAL aspects of the GnRH receptor and its signaling properties and secretory actions have been previously described (1–5). The characterization of GnRH receptors, their physiological regulation,Expand
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Angiotensin receptors and their antagonists.
Angiotensins are peptide hormones derived from the protein precursor angiotensinogen by the sequential actions of proteolytic enzymes (Figure 1). The classic pathway of angiotensin synthesis includesExpand
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Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor
Agonist-induced endocytosis and processing of the G protein–coupled AT1 angiotensin II (Ang II) receptor (AT1R) was studied in HEK 293 cells expressing green fluorescent protein (GFP)– orExpand
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Cloning and Expression of cDNA Encoding a Rat Adrenomedullin Receptor (*)
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. Its actions are mediated through an abundant class of specific binding sites that activateExpand
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Corticotropin releasing hormone receptors: two decades later
Hypothalamic corticotropin releasing hormone (CRH) regulates pituitary ACTH secretion and mediates behavioral and autonomic responses to stress, through interaction with type 1 plasma membraneExpand
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Effects of Second Intracellular Loop Mutations on Signal Transduction and Internalization of the Gonadotropin-releasing Hormone Receptor (*)
The gonadotropin-releasing hormone (GnRH) receptor belongs to the superfamily of heptahelical G protein coupled receptors, most of which have a highly conserved DRYXXV/IXXPL sequence in the secondExpand
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Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization.
The GnRH receptor is an unusual member of the G protein-coupled receptor (GPCR) superfamily with several unique features. One of these is a variant of the conserved DRY motif that is located at theExpand
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