• Publications
  • Influence
Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor
TLDR
Data indicate that internalized AT1 receptors are processed via vesicles that resemble multivesicular bodies, and recycle to the cell surface by a rapid PI 3-kinase–dependent recycling route, as well as by a slower pathway that is less sensitive to PI 3,kinase inhibitors. Expand
Properties of angiotensin II receptors in the bovine and rat adrenal cortex.
TLDR
The presence of high affinity specific binding sites for angiotensin II in bovine and rat adrenal cortex and suggest a plasma membrane location for the angiotENSin II receptors are illustrated. Expand
Hormonal regulation of androgen production by the Leydig cell.
TLDR
After exposure to increased LH and hCG levels in vivo and in vitro, LH receptors show an initial transient increase followed by a marked decrease and a prolonged depletion of LH receptor sites, suggesting that nucleotide-induced phosphorylation is related to activation of the catalytic cyclase unit. Expand
Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction.
TLDR
It is demonstrated that endocytosis of the AT1 receptor is independent of agonist-activated signal transduction and indicate that receptor internalization and activation of phospholipase C have different structural requirements. Expand
Multiple pathways of inositol polyphosphate metabolism in angiotensin-stimulated adrenal glomerulosa cells.
TLDR
Results indicate that prolonged exposure to angiotensin II in the presence of Li+ caused a progressive decline in inositol polyphosphate formation without depletion of the lipid precursor, phosphatidyl-inositol 4,5-bisph phosphate, suggesting that an accumulating product ofpolyphosphoinositide hydrolysis has an inhibitory effect on the phospholipase C-catalyzed breakdown process. Expand
A Conserved NPLFY Sequence Contributes to Agonist Binding and Signal Transduction but Is Not an Internalization Signal for the Type 1 Angiotensin II Receptor (*)
TLDR
It is demonstrated that the NPLFY sequence of the type 1a angiotensin II receptor is not an important determinant of agonist-induced internalization, however, the Phe301 residue contributes significantly to agonist binding, and Asn298 is required for normal receptor activation and signal transduction. Expand
Properties of AT1a and AT1b angiotensin receptors expressed in adrenocortical Y-1 cells.
TLDR
AT1a and AT1b receptors show small but significant differences in their binding pharmacology and, upon activation, are coupled through Gq/G11 to the phosphoinositide-Ca2+ signaling pathway, but neither AT1a nor AT1B receptors exhibit coupling to Gi and inhibition of adenylate cyclase when expressed in murine adrenal tumor cells. Expand
Circulating angiotensin II and adrenal receptors after nephrectomy
TLDR
It is shown that hyperkalaemia contributes markedly to the post-nephrectomy increase in adrenal angiotensin II receptors, and that circulating angiotENSin II levels persist for an unexpectedly long period after nephrectomy, presumably due to tissue generation of the octapeptide. Expand
Angiotensin II receptor subtypes and biological responses in the adrenal cortex and medulla.
TLDR
It is suggested that the known effects of AII in adrenal glomerulosa cells are mediated through the AT1 receptor subtype and that the distribution and/or specificity of the AT2 receptors shows marked species variations. Expand
Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, angiotensin II.
TLDR
The finding that AII enhances ACTH-stimulated production of cAMP by a second messenger-mediated mechanism that involves the participation of calcineurin reveals an additional mode of cross-talk between pathways activated by Ca(2+)-mobilizing and cAMP-generating receptors. Expand
...
1
2
3
4
5
...