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ATR protein, human

Known as: FRAP-Related Protein-1, ATR serine-threonine kinase protein, human, Ataxia Telangiectasia and Rad3 Related Protein 
Serine/threonine-protein kinase ATR (2644 aa, ~301 kDa) is encoded by the human ATR gene. This protein plays a role in protein phosphorylation, DNA… 
National Institutes of Health

Related topics

Related topics

19 relations
ATR geneATR wt AlleleCasein Kinase I Isoform Delta, humanCell Cycle

Broader (1)

Ataxia Telangiectasia Mutated Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
Highly Cited
2006
Highly Cited
2006
ATR‐dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
The phosphatidyl inositol 3‐kinase‐like kinases (PIKKs), ataxia‐telangiectasia mutated (ATM) and ATM‐ and Rad3‐related (ATR… 
Highly Cited
2003
Highly Cited
2003
DNA Damage Foci at Dysfunctional Telomeres
Highly Cited
2003
Highly Cited
2003
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.
A Cre/lox-conditional mouse line was generated to evaluate the role of ATR in checkpoint responses to ionizing radiation (IR) and… 
Highly Cited
2002
Highly Cited
2002
Hypoxia Links ATR and p53 through Replication Arrest
ABSTRACT Previous studies have demonstrated that phosphorylation of human p53 on serine 15 contributes to protein stabilization… 
Highly Cited
2001
Highly Cited
2001
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
ABSTRACT Chk1 is an evolutionarily conserved protein kinase that regulates cell cycle progression in response to checkpoint… 
Highly Cited
2001
Highly Cited
2001
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
Previous work has established a role for p53 in triggering apoptosis in response to DNA damage; p53 also induces apoptosis in… 
Highly Cited
2000
Highly Cited
2000
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.
The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been… 
Highly Cited
2000
Highly Cited
2000
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts.
The checkpoint kinase Xchk1 becomes phosphorylated in Xenopus egg extracts in response to DNA replication blocks or UV-damaged… 
Highly Cited
1999
Highly Cited
1999
A role for ATR in the DNA damage-induced phosphorylation of p53.
Phosphorylation at Ser-15 may be a critical event in the up-regulation and functional activation of p53 during cellular stress… 
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