ARGINASE

Known as: canavanase, Liver Immunoregulatory Protein, Arginase [Chemical/Ingredient] 
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Myeloid-derived suppressor cells (MDSC) producing arginase I are increased in the peripheral blood of patients with renal cell… (More)
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Review
2009
Review
2009
The enzyme arginase metabolizes L-arginine to L-ornithine and urea. Besides its fundamental role in the hepatic urea cycle… (More)
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Review
2008
Review
2008
Vascular and associated ventricular stiffness is one of the hallmarks of the aging cardiovascular system. Both an increase in… (More)
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Highly Cited
2008
Highly Cited
2008
Toll-like receptor (TLR) signaling in macrophages is required for antipathogen responses, including the biosynthesis of nitric… (More)
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Highly Cited
2007
Highly Cited
2007
Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized… (More)
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Review
2007
Review
2007
Tumor-induced tolerance is a well-established phenomenon in cancer patients that can severely impair the therapeutic efficacy of… (More)
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Highly Cited
2005
Highly Cited
2005
Myeloid suppressor cells (MSCs) producing high levels of arginase I block T cell function by depleting l-arginine in cancer… (More)
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Highly Cited
2004
Highly Cited
2004
T cells infiltrating tumors have a decreased expression of signal transduction proteins, a diminished ability to proliferate, and… (More)
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Highly Cited
1999
Highly Cited
1999
Activated murine macrophages metabolize arginine by two alternative pathways involving the enzymes inducible NO synthase (iNOS… (More)
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Review
1998
Review
1998
Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for the synthesis not only of proteins… (More)
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