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ARGINASE

Known as: canavanase, Liver Immunoregulatory Protein, Arginase [Chemical/Ingredient] 
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes… 
National Institutes of Health

Related topics

Related topics

19 relations
ARG1 geneArginase:CCnc:Pt:RBC:QnHyperargininemiaIn Blood

Broader (1)

Amidohydrolases

Narrower (8)

Arg2 protein, mouseArg2 protein, ratArginase A1Arginase-1, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms
Macrophages in granulomas are both antimycobacterial effector and host cell for Mycobacterium tuberculosis, yet basic aspects of… 
Review
2011
Review
2011
Myeloid derived suppressor cells in human diseases.
Highly Cited
2010
Highly Cited
2010
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.
Myeloid-derived suppressor cells (MDSCs) are a well-defined population of cells that accumulate in the tissue of tumor-bearing… 
Review
2010
Review
2010
Modulation of the Arginase Pathway in the Context of Microbial Pathogenesis: A Metabolic Enzyme Moonlighting as an Immune Modulator
Arginine is a crucial amino acid that serves to modulate the cellular immune response during infection. Arginine is also a common… 
Review
2007
Review
2007
Arginase, Prostaglandins, and Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma
Tumor-induced tolerance is a well-established phenomenon in cancer patients that can severely impair the therapeutic efficacy of… 
Highly Cited
2001
Highly Cited
2001
Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide‐mediated vasodilatory function
Arginase shares a common substrate, L‐arginine, with nitric oxide (NO) synthase (NOS). It is thought that arginase, if it is… 
Review
2001
Review
2001
Arginine metabolism and the synthesis of nitric oxide in the nervous system
Highly Cited
1996
Highly Cited
1996
Structure of a unique binuclear manganese cluster in arginase
EACH individual excretes roughly 10 kg of urea per year, as a result of the hydrolysis of arginine in the final cytosolic step of… 
Highly Cited
1978
Highly Cited
1978
Activated macrophages kill tumour cells by releasing arginase
WHEN rodent peritoneal exudate macrophages are exposed to stimuli such as zymosan, bacterial lipopolysaccharide (LPS) or… 
Highly Cited
1965
Highly Cited
1965
THE ROLES OF SYNTHESIS AND DEGRADATION IN THE CONTROL OF RAT LIVER TRYPTOPHAN PYRROLASE.
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