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Glutathione metabolism and its implications for health.
Animal and human studies demonstrate that adequate protein nutrition is crucial for the maintenance of GSH homeostasis, and compelling evidence shows that GSH synthesis is regulated primarily by gamma-glutamylcysteine synthetase activity, cysteine availability, and GSH feedback inhibition. Expand
Amino acids: metabolism, functions, and nutrition
  • Guoyao Wu
  • Biology, Medicine
  • Amino Acids
  • 20 March 2009
Dietary supplementation with one or a mixture of these functional AA, which include arginine, cysteine, glutamine, leucine, proline, and tryptophan, may be beneficial for ameliorating health problems at various stages of the life cycle and optimizing efficiency of metabolic transformations to enhance muscle growth, milk production, egg and meat quality and athletic performance. Expand
Free radicals, antioxidants, and nutrition.
The knowledge of enzymatic and non-enzymatic oxidative defense mechanisms will serve as a guiding principle for establishing the most effective nutrition support to ensure the biological safety of manned space missions. Expand
Amino acids and immune function
Increasing evidence shows that dietary supplementation of specific amino acids to animals and humans with malnutrition and infectious disease enhances the immune status, thereby reducing morbidity and mortality. Expand
Arginine metabolism and nutrition in growth, health and disease
The results of both experimental and clinical studies indicate that Arg is a nutritionally essential amino acid (AA) for spermatogenesis, embryonic survival, fetal and neonatal growth, as well as maintenance of vascular tone and hemodynamics and novel and effective therapies for obesity, diabetes, and the metabolic syndrome. Expand
New developments in fish amino acid nutrition: towards functional and environmentally oriented aquafeeds
Dietary supplementation with specific amino acids may be beneficial for increasing the chemo-attractive property and nutritional value of aquafeeds with low fishmeal inclusion, and enhancing immunity and tolerance to environmental stresses. Expand
Maternal nutrition and fetal development.
There is growing evidence that maternal nutritional status can alter the epigenetic state (stable alterations of gene expression through DNA methylation and histone modifications) of the fetal genome, which may provide a molecular mechanism for the impact of maternal nutrition on both fetal programming and genomic imprinting. Expand
Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates.
Modulation of the arginine-NO pathway through dietary supplementation with L-arginine or L-citrulline may aid in the prevention and treatment of the metabolic syndrome in obese humans and companion animals, and in reducing unfavorable fat mass in animals of agricultural importance. Expand
Dietary L-arginine supplementation enhances the reproductive performance of gilts.
Testing the hypothesis that dietary l-arginine supplementation may improve reproductive performance of pregnant gilts provided the first evidence for a marked increase of live-born piglets by 2 per litter through nutritional intervention in gilts. Expand
Comparative aspects of implantation.
There is compelling evidence that uterine receptivity to implantation involves temporal and cell-specific expression of interferon (IFN)-stimulated genes that have many roles including nutrient transport, cellular remodeling, angiogenesis and relaxation of vascular tissues, cell proliferation and migration, establishment of an antiviral state, and protection of conceptus tissues from challenges by the maternal immune cells. Expand