Arginase-1, human

Known as: EC 3.5.3.1, ARGI, human, Type I Arginase 
Arginase-1 (322 aa, ~35 kDa) is encoded by the human ARG1 gene. This protein plays a role in the cleavage of L-arginine to L-ornithine and urea.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1964-2018
020406019642018

Papers overview

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2013
2013
Murine macrophages are activated by interferon-γ (IFN-γ) and/or Toll-like receptor (TLR) agonists such as bacterial endotoxin… (More)
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2012
2012
Aging affects many aspects of the cellular function of macrophages. Macrophages play a critical role in innate immunity, acting… (More)
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2011
Highly Cited
2011
The ROP16 kinase of Toxoplasma gondii is injected into the host cell cytosol where it activates signal transducer and activator… (More)
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2011
2011
The use of cerium compounds as diesel fuel catalyst results in the emission of cerium oxide nanoparticles (CeO2) in the exhaust… (More)
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2010
Highly Cited
2010
Myeloid-derived suppressor cells (MDSCs) are a well-defined population of cells that accumulate in the tissue of tumor-bearing… (More)
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2010
Highly Cited
2010
Tumor immune tolerance can derive from the recruitment of suppressor cell populations, including myeloid-derived suppressor cells… (More)
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2010
2010
The distinction of hepatocellular carcinoma (HCC) from metastatic tumor in the liver often presents a diagnostic challenge that… (More)
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2009
Highly Cited
2009
Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by… (More)
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2009
Highly Cited
2009
Elevated IL-10 has been implicated in reactivation tuberculosis (TB). Since macrophages rather than T cells were reported to be… (More)
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1997
Highly Cited
1997
Nitric oxide is synthesized by nitric-oxide synthase from arginine, a common substrate of arginase. Rat peritoneal macrophages… (More)
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