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Arginase-1, human

Known as: EC 3.5.3.1, ARGI, human, Type I Arginase 
Arginase-1 (322 aa, ~35 kDa) is encoded by the human ARG1 gene. This protein plays a role in the cleavage of L-arginine to L-ornithine and urea.
National Institutes of Health

Related topics

Related topics

8 relations
ARG1 geneBiogenic Amine Metabolic ProcessCatabolic ProcessCytoplasm

Broader (2)

ARGINASEArginase A1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
Tumor-driven immune suppression is a major barrier to successful immunotherapy in ovarian carcinomas (OvCa). Among various… 
Highly Cited
2016
Highly Cited
2016
Arginase 1 is an innate lymphoid cell-intrinsic metabolic checkpoint controlling type 2 inflammation
Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair after activation by cell-extrinsic factors such as… 
Highly Cited
2016
Highly Cited
2016
Arginase-1–dependent promotion of TH17 differentiation and disease progression by MDSCs in systemic lupus erythematosus
MDSCs promote TH17 differentiation and systemic lupus erythematosus via arginase-1 production in patients and humanized mice… 
Highly Cited
2015
Highly Cited
2015
Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13.
Highly Cited
2014
Highly Cited
2014
ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment
Tumor microenvironment of solid tumors is characterized by a strikingly high concentration of adenosine and ATP. Physiological… 
Highly Cited
2014
Highly Cited
2014
Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas
Significance Tuberculosis (TB) granulomas represent sites of both bacterial containment and tissue pathology. Macrophage killing… 
Highly Cited
2012
Highly Cited
2012
Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells in cancer patients and tumor… 
Highly Cited
2010
Highly Cited
2010
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.
Myeloid-derived suppressor cells (MDSCs) are a well-defined population of cells that accumulate in the tissue of tumor-bearing… 
Review
2007
Review
2007
Pathways Mediating the Expansion and Immunosuppressive Activity of Myeloid-Derived Suppressor Cells and Their Relevance to Cancer Therapy
Cancer immunotherapy has focused on inducing and expanding CTLs and improving the immune recognition of weak antigenic… 
Highly Cited
1997
Highly Cited
1997
Coinduction of Nitric-oxide Synthase and Arginase I in Cultured Rat Peritoneal Macrophages and Rat Tissues in Vivo by Lipopolysaccharide*
Nitric oxide is synthesized by nitric-oxide synthase from arginine, a common substrate of arginase. Rat peritoneal macrophages… 
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