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Arginase-1, human

Known as: EC 3.5.3.1, ARGI, human, Type I Arginase 
Arginase-1 (322 aa, ~35 kDa) is encoded by the human ARG1 gene. This protein plays a role in the cleavage of L-arginine to L-ornithine and urea.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair after activation by cell-extrinsic factors such as… Expand
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Highly Cited
2016
Highly Cited
2016
MDSCs promote TH17 differentiation and systemic lupus erythematosus via arginase-1 production in patients and humanized mice… Expand
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Highly Cited
2014
Highly Cited
2014
Mesenchymal stem cells (MSCs) have been widely studied for their applications in stem cell-based regeneration. During myocardial… Expand
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Highly Cited
2014
Highly Cited
2014
Significance Tuberculosis (TB) granulomas represent sites of both bacterial containment and tissue pathology. Macrophage killing… Expand
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Highly Cited
2012
Highly Cited
2012
Distinction of liver metastases from hepatocellular carcinoma (HCC) may present a diagnostic challenge. Arginase-1 (Arg-1) is a… Expand
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Highly Cited
2011
Highly Cited
2011
The ROP16 kinase of Toxoplasma gondii is injected into the host cell cytosol where it activates signal transducer and activator… Expand
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Highly Cited
2010
Highly Cited
2010
Myeloid-derived suppressor cells (MDSCs) are a well-defined population of cells that accumulate in the tissue of tumor-bearing… Expand
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Highly Cited
2010
Highly Cited
2010
The distinction of hepatocellular carcinoma (HCC) from metastatic tumor in the liver often presents a diagnostic challenge that… Expand
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Highly Cited
2009
Highly Cited
2009
Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by… Expand
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Highly Cited
1997
Highly Cited
1997
Nitric oxide is synthesized by nitric-oxide synthase from arginine, a common substrate of arginase. Rat peritoneal macrophages… Expand
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