T. Cooper

Publications197
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Citations6,751
Highly Influential Citations319
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Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots.
  • T. Cooper
  • Biology
    FEMS microbiology reviews
  • 1 August 2002
Major advances have recently occurred in our understanding of GATA factor-mediated, nitrogen catabolite repression (NCR)-sensitive gene expression in Saccharomyces cerevisiae. Under nitrogen-rich…
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Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae
TLDR
It is shown that a fourth member of the yeast GATA family, the Dal80p homolog Deh1p, also negatively regulates expression of some, but not all, nitrogen catabolic genes, i.e., GAP1, DAL80, and UGA4 expression increases in a deh1 delta mutant.
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Nitrogen Metabolism in Saccharomyces cerevisiae
TLDR
In decaying fruit and vegetable matter, yeast cells encounter a broad spectrum of compounds able to serve as nitrogen sources, and Saccharomyces cerevisiae has evolved equally broad degradative enzyme systems and sophisticated ways of regulating and integrating their operation.
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Gat1p, a GATA family protein whose production is sensitive to nitrogen catabolite repression, participates in transcriptional activation of nitrogen-catabolic genes in Saccharomyces cerevisiae
TLDR
It is demonstrated that another positive regulator, designated Gat1p, participates in the transcription of NCR-sensitive genes and is able to weakly activate transcription when tethered upstream of a reporter gene devoid of upstream activation sequence elements.
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Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae.
TLDR
Results obtained with null mutations in these genes suggest that S. cerevisiae contains at least one and perhaps two additional malate synthase genes.
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Regulatory circuit for responses of nitrogen catabolic gene expression to the GLN3 and DAL80 proteins and nitrogen catabolite repression in Saccharomyces cerevisiae
TLDR
It is demonstrated that expression of the UGA1, CAN1, GAP1, PUT1,PUT2, P UT4, and DAL4 genes is sensitive to nitrogen catabolite repression and these genes also responded to disruption of DAL80.
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The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site.
TLDR
It is shown here that the UME6 gene product is required for URS1 to mediate repression of gene expression in the absence of inducer.
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Ure2, a Prion Precursor with Homology to Glutathione S-Transferase, Protects Saccharomyces cerevisiae Cells from Heavy Metal Ion and Oxidant Toxicity*
TLDR
It is shown that Ure2 is required for detoxification of glutathione S-transferase substrates and cellular oxidants, and mutations in ure2 mutations possess the same phenotypes as mutations in known S. cerevisiae and Schizosaccharomyces pombeglutathione GATA factor genes.
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Ubiquitous upstream repression sequences control activation of the inducible arginase gene in yeast.
TLDR
Data suggest the URS identified in this work is a generic repressor target site that apparently has been conserved during the evolution of transcriptional regulatory systems.
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Regulation of the urea active transporter gene (DUR3) in Saccharomyces cerevisiae
TLDR
Strong negative complementation observed during genetic analysis of the D UR3 locus suggests that the DUR3 product may polymerize to carry out its physiological function.
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