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APP protein, human

Known as: AAA, ABPP, APP 
Amyloid beta A4 protein (770 aa, ~87 kDa) is encoded by the human APP gene. This protein is involved in cell surface receptor-mediated signaling and… 
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Peptides or proteins convert under some conditions from their soluble forms into highly ordered fibrillar aggregates. Such… 
Highly Cited
2006
Highly Cited
2006
We report duplication of the APP locus on chromosome 21 in five families with autosomal dominant early-onset Alzheimer disease… 
Highly Cited
2003
Highly Cited
2003
Highly Cited
2003
Highly Cited
2003
Alzheimer's disease is associated with increased production and aggregation of amyloid-β (Aβ) peptides. Aβ peptides are derived… 
Highly Cited
2000
Highly Cited
2000
CONTEXT Alzheimer disease (AD) is characterized neuropathologically by the presence of amyloid beta-peptide (Abeta)-containing… 
Highly Cited
1999
Highly Cited
1999
Proteolytic processing of the amyloid precursor protein (APP) generates amyloid β (Aβ) peptide, which is thought to be causal for… 
Highly Cited
1999
Highly Cited
1999
Amyloid beta peptide (Abeta), the principal proteinaceous component of amyloid plaques in brains of Alzheimer's disease patients… 
Highly Cited
1999
Highly Cited
1999
Amyloid-β peptide (Aβ) seems to have a central role in the neuropathology of Alzheimer's disease (AD). Familial forms of the… 
Highly Cited
1998
Highly Cited
1998
Point mutations in the presenilin-1 gene (PS1) are a major cause of familial Alzheimer's disease. They result in a selective… 
Highly Cited
1996
Highly Cited
1996
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid β-protein precursor (APP) mutations linked to…