APP protein, human

Known as: AAA, ABPP, APP 
Amyloid beta A4 protein (770 aa, ~87 kDa) is encoded by the human APP gene. This protein is involved in cell surface receptor-mediated signaling and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1960-2018
020040019602018

Papers overview

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Review
2016
Review
2016
Over the past 30years the mitochondrial permeability transition - the permeabilization of the inner mitochondrial membrane due to… (More)
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Review
2015
Review
2015
Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ fragments of APP are the major constituent of… (More)
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Highly Cited
2009
Highly Cited
2009
Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal connections during development, but their… (More)
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Highly Cited
2006
Highly Cited
2006
We report duplication of the APP locus on chromosome 21 in five families with autosomal dominant early-onset Alzheimer disease… (More)
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Highly Cited
2006
Highly Cited
2006
Memory function often declines with age, and is believed to deteriorate initially because of changes in synaptic function rather… (More)
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Highly Cited
2005
Highly Cited
2005
Biochemical and genetic studies place the amyloid precursor protein (APP) at the center stage of Alzheimer's disease (AD… (More)
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Highly Cited
2003
Highly Cited
2003
A large body of evidence has implicated Abeta peptides and other derivatives of the amyloid precursor protein (APP) as central to… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND AD is characterized by cerebral deposition of beta-amyloid plaques with amyloid beta-peptide (Abeta) 42 as the major… (More)
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Highly Cited
2001
Highly Cited
2001
Several pathogenic Alzheimer's disease (AD) mutations have been described, all of which cause increased amyloid β-protein (A… (More)
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Highly Cited
2000
Highly Cited
2000
CONTEXT Alzheimer disease (AD) is characterized neuropathologically by the presence of amyloid beta-peptide (Abeta)-containing… (More)
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