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APP protein, human

Known as: AAA, ABPP, APP 
Amyloid beta A4 protein (770 aa, ~87 kDa) is encoded by the human APP gene. This protein is involved in cell surface receptor-mediated signaling and… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Background Emerging research suggests that mobile apps can be used to effectively treat common mental illnesses like depression… Expand
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Review
2012
Review
2012
Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks of Alzheimer disease. Amyloid β-peptide… Expand
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Highly Cited
2006
Highly Cited
2006
We report duplication of the APP locus on chromosome 21 in five families with autosomal dominant early-onset Alzheimer disease… Expand
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Highly Cited
2003
Highly Cited
2003
A large body of evidence has implicated Abeta peptides and other derivatives of the amyloid precursor protein (APP) as central to… Expand
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Highly Cited
2001
Highly Cited
2001
Several pathogenic Alzheimer's disease (AD) mutations have been described, all of which cause increased amyloid β-protein (A… Expand
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Highly Cited
2001
Highly Cited
2001
In eukaryotic cells, incorrectly folded proteins in the endoplasmic reticulum (ER) are exported into the cytosol and degraded by… Expand
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Highly Cited
1999
Highly Cited
1999
Proteolytic processing of the amyloid precursor protein (APP) generates amyloid β (Aβ) peptide, which is thought to be causal for… Expand
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Highly Cited
1999
Highly Cited
1999
Amyloid-β peptide (Aβ) seems to have a central role in the neuropathology of Alzheimer's disease (AD). Familial forms of the… Expand
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Highly Cited
1998
Highly Cited
1998
Point mutations in the presenilin-1 gene (PS1) are a major cause of familial Alzheimer's disease. They result in a selective… Expand
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Highly Cited
1996
Highly Cited
1996
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid β-protein precursor (APP) mutations linked to… Expand
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