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APP protein, human

Known as: AAA, ABPP, APP 
Amyloid beta A4 protein (770 aa, ~87 kDa) is encoded by the human APP gene. This protein is involved in cell surface receptor-mediated signaling and… 
National Institutes of Health

Related topics

Related topics

24 relations
APP geneAPP wt AlleleAlzheimer's DiseaseAlzheimer's Disease Pathway KEGG

Broader (2)

AmyloidAmyloid beta-Protein Precursor

Narrower (1)

beta-sAPP protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Corrigendum: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques
Nature Communications 6: Article number: 8997 (2015); Published: 8 December 2015; Updated: 15 February 2016 This Article contains… 
Highly Cited
2010
Highly Cited
2010
Thermodynamic analysis of the molecular interactions between amyloid beta-peptide 42 and (-)-epigallocatechin-3-gallate.
One of the key factors of Alzheimer's disease (AD) is the conversion of amyloid beta-peptide (Abeta) from its soluble random coil… 
Highly Cited
2009
Highly Cited
2009
Comparison of dopants for charge exchange ionization of nonpolar polycyclic aromatic hydrocarbons with reversed-phase LC-APPI-MS
Highly Cited
2006
Highly Cited
2006
Comparative study of electrospray and photospray ionization sources coupled to quadrupole time-of-flight mass spectrometer for olive oil authentication.
Highly Cited
2005
Highly Cited
2005
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
Alzheimer's disease (AD) is characterized by accumulation of the neurotoxic peptide beta-amyloid, which is produced by… 
Highly Cited
2002
Highly Cited
2002
Impaired Eyeblink Conditioning and Decreased Hippocampal Volume in PDAPP V717F Mice
We examined heterozygous transgenic (Tg) mice that overexpress V717F amyloid precursor protein (APP) for delay eyeblink… 
Highly Cited
2000
Highly Cited
2000
Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway.
Cerebral deposits of beta-amyloid (betaA) are a major feature in Alzheimer's disease. betaA is derived from amyloid precursor… 
Highly Cited
2000
Highly Cited
2000
In Vivo 2-Deoxyglucose Administration Preserves Glucose and Glutamate Transport and Mitochondrial Function in Cortical Synaptic Terminals after Exposure to Amyloid β-Peptide and Iron: Evidence for…
Mild metabolic stress can increase resistance of neurons in the brain to subsequent more severe insults, as exemplified by the… 
Highly Cited
1998
Highly Cited
1998
ATP-dependent Proteolysis in Mitochondria
To analyze protein degradation in mitochondria and the role of molecular chaperone proteins in this process, bovine apocytochrome… 
Highly Cited
1994
Highly Cited
1994
The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment.
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