• Publications
  • Influence
Accelerating the convergence of the back-propagation method
Considering the selection of weights in neural nets as a problem in classical nonlinear optimization theory, the rationale for algorithms seeking only those weights that produce the globally minimum error is reviewed and rejected.
Insulin and the insulin receptor in experimental models of learning and memory.
Emerging evidence has suggested that insulin signaling plays a role in synaptic plasticity by modulating activities of excitatory and inhibitory receptors such as glutamate and GABA receptors, and by triggering signal transduction cascades leading to alteration of gene expression required for long-term memory consolidation.
Intracellular Correlates of Acquisition and Long-Term Memory of Classical Conditioning in Purkinje Cell Dendrites in Slices of Rabbit Cerebellar Lobule HVI
The pharmacological data suggest a role for potassium channels and, possibly, channels mediating an IA-like current, in learning-specific changes in membrane excitability, and a strong relationship between the level of conditioning and Purkinje cell dendritic membrane excitable after initial acquisition of the conditioned response.
Role of insulin and insulin receptor in learning and memory
Accumulated evidence has demonstrated that insulin/IR plays important roles in associative learning, as suggested by results from both interventive and correlative studies.
Calcium-mediated reduction of ionic currents: a biophysical memory trace.
  • D. Alkon
  • Biology, Medicine
  • 30 November 1984
Specific ionic currents in neural tissue undergo transformations lasting days after associative training with physiologic stimuli, and hence this biophysical basis of Hermissenda learning could have relevance for species other than the gastropod studied.
Memory-specific temporal profiles of gene expression in the hippocampus
Results of this study suggest that while learning and physical activity involve common groups of genes, the behavior of learning and memory emerges from unique patterns of gene expression across time.
Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway.
It is shown that in human neuroblastoma SH-SY5Y cells, neuron-specific ELAV (nELAV) proteins are up-regulated and redistributed by 15 min of treatment with the activators of PKC phorbol esters and bryostatin-1, and in vivo PKC activation is associated with an up-regulation of nELAV proteins in the hippocampal rat brain.
PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease.
This conceptual framework as a basis for an autopsy-validated peripheral biomarker and for AD drug design targeting drugs (bryostatin and bryologs) that activate PKC isozymes--that has already demonstrated significant promise for treating both AD neurodegeneration and its symptomatic memory loss are discussed.