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Brain Insulin Receptors and Spatial Memory
Evidence accumulated from clinical and basic research has indirectly implicated the insulin receptor (IR) in brain cognitive functions, including learning and memory (Wickelgren, I. (1998) ScienceExpand
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Accelerating the convergence of the back-propagation method
The utility of the back-propagation method in establishing suitable weights in a distributed adaptive network has been demonstrated repeatedly. Expand
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Insulin and the insulin receptor in experimental models of learning and memory.
Insulin is best known for its action on peripheral insulin target tissues such as the adipocyte, muscle and liver to regulate glucose homeostasis. In the central nervous system (CNS), insulin and theExpand
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Intracellular Correlates of Acquisition and Long-Term Memory of Classical Conditioning in Purkinje Cell Dendrites in Slices of Rabbit Cerebellar Lobule HVI
Intradendritic recordings in Purkinje cells from a defined area in parasaggital slices of cerebellar lobule HVI, obtained after rabbits were given either paired (classical conditioning) or explicitlyExpand
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Role of insulin and insulin receptor in learning and memory
As one of the most extensively studied protein hormones, insulin and its receptor have been known to play key roles in a variety of important biological functions. Until recent years, the functionsExpand
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Calcium-mediated reduction of ionic currents: a biophysical memory trace.
  • D. Alkon
  • Biology, Medicine
  • Science
  • 30 November 1984
Learning behavior similar to vertebrate classical conditioning was demonstrated for the mollusc Hermissenda crassicornis. Postsynaptic membrane changes within well-defined neural systems that mediateExpand
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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.
  • E. Ito, K. Oka, +5 authors D. Alkon
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 18 January 1994
The recent demonstration of K+ channel dysfunction in fibroblasts from Alzheimer disease (AD) patients and past observations of Ca(2+)-mediated K+ channel modulation during memory storage suggestedExpand
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Memory-specific temporal profiles of gene expression in the hippocampus
Many experiments in the past have demonstrated the requirement of de novo gene expression during the long-term retention of learning and memory. Although previous studies implicated individual genesExpand
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Associative Behavioral Modification in Hermissenda: Cellular Correlates
Three days of training consisting of trials of light paired with rotation produces a long-term modification of photopositive behavior in Hermissenda crassicornis. The behavioral modification dependsExpand
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