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APP gene

Known as: AAA, APP, amyloid beta precursor protein 
This gene is involved in transcriptional activation and mutations in the gene are correlated with Alzheimer disease.
National Institutes of Health

Related topics

Related topics

16 relations
ALZHEIMER DISEASE, FAMILIAL, 1APP protein, humanAPP wt AlleleAlzheimer's Disease

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators*♦
Pathogenic generation of the 42-amino acid variant of the amyloid β-peptide (Aβ) by β- and γ-secretase cleavage of the β-amyloid… 
Review
2004
Review
2004
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases.
Loci underlying autosomal dominant forms of most neurodegenerative disease have been identified: prion mutations cause Gerstmann… 
Highly Cited
2004
Highly Cited
2004
Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations
Hereditary spastic paraplegia (HSP) is a genetically heterogeneous neurodegenerative disease characterized by wide variability in… 
Highly Cited
2001
Highly Cited
2001
Functional Analysis of the Trypanosomal AAA ProteinTbVCP with trans-Dominant ATP Hydrolysis Mutants*
TbVCP is a member of the AAA (ATPases Associated with a variety of cellularActivities) family of proteins containing two ATPase… 
Review
2000
Review
2000
Modeling Alzheimer's disease in transgenic mice: effect of age and of Presenilin1 on amyloid biochemistry and pathology in APP/London mice
Highly Cited
1999
Highly Cited
1999
The Janus Face of the Archaeal Cdc48/p97 Homologue VAT: Protein Folding versus Unfolding
Abstract Members of the AAA family of ATPases have been implicated in chaperone-like activities. We used the archaeal Cdc48/p97… 
Highly Cited
1996
Highly Cited
1996
Hairpin loops consisting of single adenine residues closed by sheared A.A and G.G pairs formed by the DNA triplets AAA and GAG: solution structure of the d(GTACAAAGTAC) hairpin.
The DNA undecamers GTACAAAGTAC (AAA 11-mer) and GTACGAGGTAC (GAG 11-mer) have been studied in solution by high-resolution NMR… 
Review
1994
Review
1994
Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans.
Highly Cited
1993
Highly Cited
1993
Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val→Ile mutation in the amyloid precursor protein gene
Highly Cited
1984
Highly Cited
1984
Codon context effects in missense suppression.
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