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APP gene

Known as: AAA, APP, amyloid beta precursor protein 
This gene is involved in transcriptional activation and mutations in the gene are correlated with Alzheimer disease.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The prevalence of dementia in the Western world in people over the age of 60 has been estimated to be greater than 5%, about two… Expand
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Highly Cited
2012
Highly Cited
2012
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes. However, the… Expand
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Highly Cited
2009
Highly Cited
2009
β-Amyloid precursor protein (APP) mutations cause familial Alzheimer's disease with nearly complete penetrance. We found an APP… Expand
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Highly Cited
2004
Highly Cited
2004
The AAA+ ATPases are enzymes containing a P-loop NTPase domain, and function as molecular chaperones, ATPase subunits of… Expand
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Highly Cited
1999
Highly Cited
1999
Using a combination of computer methods for iterative database searches and multiple sequence alignment, we show that protein… Expand
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Highly Cited
1999
Highly Cited
1999
Autosomal dominant hereditary spastic paraplegia (AD-HSP) is a genetically heterogeneous neurodegenerative disorder characterized… Expand
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Highly Cited
1997
Highly Cited
1997
We have isolated the gene for a protein designated CCA1. This protein can bind to a region of the promoter of an Arabidopsis… Expand
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Highly Cited
1996
Highly Cited
1996
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to… Expand
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Highly Cited
1994
Highly Cited
1994
Normal processing of the amyloid beta protein precursor (beta APP) results in secretion of a soluble 4-kilodalton protein… Expand
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Highly Cited
1992
Highly Cited
1992
Mutations at codon 717 in exon 17 of the β–amyloid precursor protein (APP) gene have previously been shown to segregate with… Expand
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