APP gene

Known as: AAA, APP, amyloid beta precursor protein 
This gene is involved in transcriptional activation and mutations in the gene are correlated with Alzheimer disease.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The prevalence of dementia in the Western world in people over the age of 60 has been estimated to be greater than 5%, about two… (More)
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Highly Cited
2012
Highly Cited
2012
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes. However, the… (More)
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Highly Cited
2009
Highly Cited
2009
beta-Amyloid precursor protein (APP) mutations cause familial Alzheimer's disease with nearly complete penetrance. We found an… (More)
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Highly Cited
2007
Highly Cited
2007
It is well established that the proteolytic processing of the beta-amyloid precursor protein (APP) generates beta-amyloid (Abeta… (More)
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Highly Cited
2006
Highly Cited
2006
We assessed the impact of amyloid precursor protein (APP) gene locus duplications in early onset Alzheimer's disease in a Dutch… (More)
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Highly Cited
2004
Highly Cited
2004
The AAA+ ATPases are enzymes containing a P-loop NTPase domain, and function as molecular chaperones, ATPase subunits of… (More)
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Highly Cited
1999
Highly Cited
1999
Using a combination of computer methods for iterative database searches and multiple sequence alignment, we show that protein… (More)
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Highly Cited
1999
Highly Cited
1999
Amyloid-β peptide (Aβ) seems to have a central role in the neuropathology of Alzheimer's disease (AD). Familial forms of the… (More)
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Highly Cited
1996
Highly Cited
1996
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to… (More)
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Highly Cited
1992
Highly Cited
1992
Mutations at codon 717 in exon 17 of the β–amyloid precursor protein (APP) gene have previously been shown to segregate with… (More)
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