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ABCC8 gene

Known as: SUR1, HI, ABC36 
National Institutes of Health

Related topics

Related topics

4 relations
ABCC11 geneHyperinsulinemic hypoglycemia, familial, 1Nesidioblastosissulfonylurea receptor

Papers overview

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Highly Cited
2012
Highly Cited
2012
The Sulfonylurea Receptor 1 (Sur1)-Transient Receptor Potential Melastatin 4 (Trpm4) Channel
Background: Sur1-NCCa-ATP channels implicated in acute CNS injury are hypothesized to be formed by co-association of Sur1 and a… 
Highly Cited
2011
Highly Cited
2011
Heterozygous ABCC8 mutations are a cause of MODY
Aims/hypothesisThe ABCC8 gene encodes the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic beta cell ATP-sensitive… 
Highly Cited
2003
Highly Cited
2003
Functional Coupling between Sulfonylurea Receptor Type 1 and a Nonselective Cation Channel in Reactive Astrocytes from Adult Rat Brain
We previously identified a novel, nonselective cation channel in native reactive (type R1) astrocytes (NR1As) from injured rat… 
Highly Cited
2001
Highly Cited
2001
Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death
The ability of the sulfonylurea receptor (SUR) 1 to suppress seizures and excitotoxic neuron damage was assessed in mice… 
Highly Cited
2000
Highly Cited
2000
The molecular basis of the specificity of action of KATP channel openers
KATP channels incorporate a regulatory subunit of the ATP‐binding cassette (ABC) transporter family, the sulfonylurea receptor… 
Highly Cited
1999
Highly Cited
1999
The C Terminus of SUR1 Is Required for Trafficking of KATP Channels*
In beta cells from the pancreas, ATP-sensitive potassium channels, or KATP channels, are composed of two subunits, SUR1 and KIR6… 
Highly Cited
1998
Highly Cited
1998
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
ATP-sensitive potassium (KATP) channels in the pancreatic beta cell membrane mediate insulin release in response to elevation of… 
Highly Cited
1997
Highly Cited
1997
Overlapping distribution of KATP channel‐forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain
Review
1997
Review
1997
Membrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transporters
Highly Cited
1997
Highly Cited
1997
Properties of cloned ATP‐sensitive K+ currents expressed in Xenopus oocytes.
1. We have studied the electrophysiological properties of cloned ATP‐sensitive K+ channels (KATP channels) heterologously… 
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